Cold Spring Harbor Laboratory Press Site Map and Book List | ||||||||||||||||||||||||||||
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Publication Date | 2005/2005 | |||||||||||||||||||||||||||
Bibliographic Information 465 pp., illus., appendices, index | ||||||||||||||||||||||||||||
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At the Bench: A Laboratory Navigator At the Helm: A Laboratory Navigator |
Title At the Helm: Leading Your Laboratory, Second Edition
Unique URL http://www.cshlpress.com/link/at_helm2.htm | ||||
ISBN | 978-0-879698-66-9 | |||
Price | $67.00 | |||
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Since 2002, the first edition of this best-selling book has helped thousands of newly appointed principal investigators successfully transition to running their own labs. But changes in technology continue to transform the way science is done, affecting ways in which labs communicate and collaborate, organize data and supplies, and keep current on the latest developments. The culture of science has also evolved, as more scientists explore non-academic career paths, seek new ways to communicate information and ideas, and acquire skills and knowledge outside of their field. In the second edition of this book, Kathy Barker has substantially revised the text, offering PIs advice on adapting to the changes and challenges that the years have brought. New topics include collaboration contracts, performance evaluations, communicating with non-scientists, tips for succeeding on the tenure track, and professional development. With this book as a guide, any new or aspiring PI will be well-equipped to manage personnel, time, and institutional responsibilities with confidence. About the author: Kathy Barker received her B.A. in Biology and English, and her M.A. and Ph.D. in Microbiology, from various branches of the University of Massachusetts. She did her postdoctoral work in the laboratory of Viral Oncology at Rockefeller University and was an Assistant Professor in the Laboratory of Cell Physiology and Immunology at Rockefeller University. She is now based in Seattle, where she writes and gives workshops on various aspects of running a lab.
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Publication Date | 2010/2010 | |||
Bibliographic Information 372 pp., illus. (2 b/w), index Trim size: 7" x 10" | ||||
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Lab Dynamics: Management Skills for Scientists At the Bench: A Laboratory Navigator, Updated Edition |
Title Auxin Signaling: From Synthesis to Systems Biology, Second Edition
Unique URL not available | ||||
ISBN | 978-1-621824-00-8 | |||
Price | $135 | |||
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Auxin is a hormone that plays a central role in plant growth, tissue patterning, organogenesis, and responses to light. Differences in auxin concentrations in different regions of the plant result in dramatic changes in gene expression, up- or down-regulating distinct sets of target genes. Recent technological advances have provided insights into mechanistic details of auxin signaling and its many roles in plant biology. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers recent insights into how auxin levels are regulated and, in turn, drive various developmental processes in plants. The contributors discuss the biosynthesis, conjugation, and degradation of auxin, the various transporters, receptors, and transcription factors involved in auxin signaling, the interactions of auxin with other plant hormones, and how these are spatiotemporally coordinated. The roles of auxin in specific organs and tissues—the shoot apical meristem, roots, vasculature, and flowers—are described in detail. The evolutionary history of auxin signaling and its roles in environmental responses (e.g., plant-pathogen interactions) are also reviewed. Other topics include the development of computational models for root and shoot growth, as well as chemical tools and synthetic systems to understand auxin biology. This volume is therefore an essential reference for all plant biologists, as well as systems biologists, biochemists, and developmental biologists interested in the regulation of plant morphogenesis and behavior. | ||||
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Publication Date | 2022/2022 | |||
Bibliographic Information 468 pages, illustrated (79 color and 4 B&W), index | ||||
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Title Bacterial Pathogenesis
Unique URL http://www.cshlpress.com/link/bacterialpath.htm | ||||
ISBN | 978-1-936113-36-1 | |||
Price | $135 | |||
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Bacterial illnesses—such as tuberculosis, pneumonia, typhoid fever, meningitis, and dysentery—are some of the most devastating worldwide. Although antibiotics and vaccines control their prevalence to some extent, the emergence of new virulence mechanisms and new forms of resistance to antibacterial agents makes research in this field critical to understanding and controlling infectious diseases. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the biology of these pathogens, their virulence mechanisms, and the host's response to infection. The contributors survey the various toxins and effectors that are used to hijack the cellular machinery of the host, and they explain how their production is coordinated and controlled. The host specificity of bacterial pathogens and the genetic basis of susceptibility are also considered. Other chapters are devoted to the pathogenic mechanisms of specific bacterial species (e.g., Salmonella, Chlamydia, and Helicobacter pylori). The authors also describe novel vaccine strategies and antimicrobial approaches (e.g., phage therapy or biofilm disruption), as well as the use of probiotics to benefit human health. This volume is thus an essential reference for microbiologists, immunologists, and cell and molecular biologists, as well as clinicians and other public health professionals. | ||||
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Publication Date | 2014/2014 | |||
Bibliographic Information 413 pages, illustrated (59 color, 10 B&W), index | ||||
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Title Basic Methods in Microscopy Protocols and Concepts from Cells: A Laboratory Manual Unique URL http://www.cshlpress.com/link/basmicp.htm | ||||
ISBN | 978-087969751-8 | |||
Price | $97.00 | |||
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Imaging has become a vital tool for researchers in all aspects of biology. Recent advances in microscope technology, labeling techniques and gene and protein manipulation methods have led to breakthroughs in our understanding of biological processes. In order to take advantage of these techniques, biologists need to understand the fundamental techniques of microscopy. The methods found here, drawn from the popular laboratory standard manual Cells: A Laboratory Manual, provide a solid course in the basics of using the microscope in a biology laboratory. Basic Methods in Microscopy provides an essential guide to light microscopy, fluorescence microscopy, confocal microscopy, multiphoton microscopy and electron microscopy, preparation of tissues and cells, labeling of specimens and analysis of cellular events. This manual is an important tool for any biology researcher employing imaging as a research method. | ||||
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Publication Date | 2006/2006 | |||
Bibliographic Information 382 pp., illus., index | ||||
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Basic Methods in Microscopy Protocols and Concepts from Cells: A Laboratory Manual |
Title Basic Methods in Protein Purification and Analysis: A Laboratory Manual
Unique URL http://www.cshlpress.com/link/bmppap.htm | ||||
ISBN | 978-087969-867-6 | |||
Price | $97 | |||
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Understanding how proteins function is an essential part of many biological research endeavors. The complexity and sheer number of proteins in a cell are impediments to identifying proteins of interest or purifying proteins for function and structure analysis. Thus, reducing the complexity of a protein sample or in some cases purifying a protein to homogeneity is necessary. The latest manual in the Basic Methods series contains a collection of convenient and easy to use protein purification protocols along with a sampling of dependable methods for assessing protein–protein interactions. The protocols are supported by background information to assist researchers in understanding how the purification methods work and how to optimize and troubleshoot the methods. The collection of essential methods found in Basic Methods in Protein Purification and Analysis is mainly drawn from the popular manuals Proteins and Proteomics, Purifying Proteins for Proteomics, and Protein–Protein Interactions, 2nd Ed. In addition to protocols for purification using gel electrophoresis and column chromatography, this book contains tested methods for preparing cellular and subcellular extracts–a critical and often neglected step in successful protein purification. Rounding out the manual are methods for characterizing protein–protein interactions, an extensive appendix of essential methods for quantifying protein concentration, stabilizing and storing proteins, concentrating proteins, and immunoblotting. Finally, there is a new chapter on a method complementary to gel electrophoresis and chromatography: in silico analysis of genomic and proteomic databases. | ||||
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Publication Date | 2009/2009 | |||
Bibliographic Information 436 pp., illus., appendices, index | ||||
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Basic Methods in Protein Purification and Analysis: A Laboratory Manual Proteins and Proteomics: A Laboratory Manual Proteins and Proteomics: A Laboratory Manual Protein-Protein Interactions: A Molecular Cloning Manual, Second Edition Protein-Protein Interactions: A Molecular Cloning Manual, Second Edition |
Title Basic Stereology for Biologists and Neuroscientists
Unique URL http://www.cshlpress.com/link/basicstereo.htm | ||||
ISBN | 978-1-936113-60-6 | |||
Price | $69 | |||
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Stereological techniques allow biologists to create quantitative, three-dimensional descriptions of biological structures from two-dimensional images of tissue viewed under the microscope. For example, they can accurately estimate the size of a particular organelle, the total length of a mass of capillaries, or the number of neurons or synapses in a particular region of the brain. This book provides a practical guide to designing and critically evaluating stereological studies of the nervous system and other tissues. It explains the basic concepts behind design-based stereology and how to get started. Also included are detailed descriptions of how to prepare tissue appropriately, perform pilot studies and decide on the appropriate sampling strategy, and account for phenomena such as tissue shrinkage. Numerous examples of applications of stereological methods that are applicable to studies of the central system and a wide variety of other tissues are explained. The book is therefore essential reading for neurobiologists and cell biologists interested in generating accurate representations of cell and tissue architecture. | ||||
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Publication Date | 2012/2012 | |||
Bibliographic Information 206 pp., illus., index | ||||
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Title Binding and Kinetics for Molecular Biologists
Unique URL http://www.cshlpress.com/link/bindkin.htm | ||||
ISBN | 978-1-621820-79-6 | |||
Price | $39 | |||
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This handbook offers a practical guide to the principles of quantitative analysis in biological experiments. The material is primarily aimed at working molecular biologists, but the scope and clarity of presentation make it equally suitable as an introduction for students. Topics covered range from the basics—such as measuring the concentrations of macromolecules—through considerations of binding constants and the kinetics of molecular interactions. The book ends with a thorough consideration of data analysis. | ||||
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Publication Date | 2007/2007 | |||
Bibliographic Information 182 pp., illus., appendices, index | ||||
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Title Bioelectronic Medicine
Unique URL not available | ||||
ISBN | 978-1-621823-02-5 | |||
Price | $135 | |||
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Every organ in the human body is innervated by the nervous system and communicates with the brain via electrical signals. Various devices can be used to modulate these electrical signals and elicit changes in organ function with the aim of treating injury or disease. This approach is the basis of the rapidly emerging field of bioelectronic medicine, which has the potential to diagnose and treat medical conditions more precisely and effectively than ever before. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers many aspects of bioelectronic medicine, examining the neuronal pathways that are being targeted for manipulation, the electronic neuromodulation devices that are under development, and how all of this work is leading to new diagnostics and treatment options for patients. The contributors discuss how the stimulation of specific nerves (e.g., the vagus nerve) has been successfully used to treat certain conditions (e.g., rheumatoid arthritis and Crohn’s disease) and how similar strategies are being investigated as therapeutics for a multitude of gastrointestinal, cardiovascular, respiratory, and renal disorders. They consider implantable devices, magnetoelectric nanoparticles, ultrasound, optogenetic-based approaches, and electrophotonic devices as tools for acquiring, decoding, and modulating electrical signals from nerves and how they might be used to monitor and treat patients in the clinic. The authors also discuss the ethical concerns related to the use of technologies such as these that can alter the brain. The volume is therefore an indispensable reference for neuroscientists, biomedical engineers, and physicians interested in the benefits and challenges of recording, stimulating, and blocking electrical activity in the human body. | ||||
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Publication Date | 2019/2019 | |||
Bibliographic Information 348 pages, illustrated (73 color and 7 B&W), index | ||||
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Title A Bioinformatics Guide for Molecular Biologists
Unique URL http://www.cshlpress.com/link/bioinfoguidemb.htm | ||||
ISBN | 978-1-936113-22-4 | |||
Price | $79 | |||
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Informatics can vastly assist progress in research and development in cell and molecular biology and biomedicine. However, many investigators are either unaware of the ways in which informatics can improve their research or find it inaccessible due to a feeling of “informatics anxiety.” This sense of apprehension results from improper communication of the principles behind these approaches and of the value of the many tools available. In fact, many researchers are inherently distrustful of these tools. A more complete understanding of bioinformatics offered in A Bioinformatics Guide for Molecular Biologists will allow the reader to become comfortable with these techniques, encouraging their use—thus helping to make sense of the vast accumulation of data. To make these concepts more accessible, the editors approach the field of bioinformatics from the viewpoint of a molecular biologist, (1) arming the biologist with a basic understanding of the fundamental concepts in the field, (2) presenting approaches for using the tools from the standpoint of the data for which they are created, and (3) showing how the field of informatics is quickly adapting to the advancements in biology and biomedical technologies. All concepts are paired with recommendations for the appropriate programming environment and tools best suited to solve the particular problem at hand. It is a must-read for those interested in learning informatics techniques required for successful research and development in the laboratory. | ||||
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Publication Date | 2014/2014 | |||
Bibliographic Information 328 pp, illus. (64 4C, 26 B&W), index | ||||
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Title Bioinformatics: Sequence and Genome Analysis, Second Edition
Unique URL http://www.cshlpress.com/link/bioinf2p.htm | ||||
ISBN | 978-087969712-9 | |||
Price | $95 | |||
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As more species' genomes are sequenced, computational analysis of these data has become increasingly important. The second, entirely updated edition of this widely praised textbook provides a comprehensive and critical examination of the computational methods needed for analyzing DNA, RNA, and protein data, as well as genomes. The book has been rewritten to make it more accessible to a wider audience, including advanced undergraduate and graduate students. New features include chapter guides and explanatory information panels and glossary terms. New chapters in this second edition cover statistical analysis of sequence alignments, computer programming for bioinformatics, and data management and mining. Practically oriented problems at the ends of chapters enhance the value of the book as a teaching resource. The book also serves as an essential reference for professionals in molecular biology, pharmaceutical, and genome laboratories. | ||||
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Publication Date | 2004/2004 | |||
Bibliographic Information 665 pp., illus., appendices, index | ||||
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Bioinformatics: Sequence and Genome Analysis, Second Edition |
Title The Biology of Alzheimer Disease
Unique URL http://www.cshlpress.com/link/bioalzdis.htm | ||||
ISBN | 978-1-936113-44-6 | |||
Price | $135 | |||
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Alzheimer disease causes the gradual deterioration of cognitive function, including severe memory loss and impairments in abstraction and reasoning. Understanding the complex changes that occur in the brain as the disease progresses—including the accumulation of amyloid plaques and neurofibrillary tangles—is critical for the development of successful therapeutic approaches.
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Publication Date | December 2011/2011 | |||
Bibliographic Information 511 pp., illus. (63 4C & 9 B&W), index | ||||
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Title Biology of Drosophila
Unique URL http://www.cshlpress.com/link/biodrosp.htm | ||||
ISBN | 978-087969828-7 | |||
Price | $42.00 | |||
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Biology of Drosophila was first published by John Wiley and Sons in 1950. Until its appearance, no central, synthesized source of biological data on Drosophila melanogaster was available, despite the fly's importance to science for three decades. Ten years in the making, it was an immediate success and remained in print for two decades. However, original copies are now very hard to find. This facsimile edition makes available to the fly community once again its most enduring work of reference. | ||||
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Publication Date | 2008/2008 | |||
Bibliographic Information 632 pp., illus., indexes | ||||
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Biology of Drosophila |
Title The Biology of Exercise
Unique URL http://www.cshlpress.com/link/bioexerp.htm | ||||
ISBN | 978-1-621822-85-1 | |||
Price | $79 | |||
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Exercise training provokes widespread transformations in the human body, requiring coordinated changes in muscle composition, blood flow, neuronal and hormonal signaling, and metabolism. These changes enhance physical performance, improve mental health, and delay the onset of aging and disease. Understanding the molecular basis of these changes is therefore important for optimizing athletic ability and for developing drugs that elicit therapeutic effects. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the biological basis of exercise from the molecular to the systemic levels. Contributors discuss how transcriptional regulation, cytokine and hormonal signaling, glucose metabolism, epigenetic modifications, microRNA profiles, and mitochondrial and ribosomal functions are altered in response to exercise training, leading to improved skeletal muscle, hippocampal, and cardiovascular functions. Cross talk among the pathways underlying tissue-specific and systemic responses to exercise is also considered. The authors also discuss how the understanding of such molecular mechanisms may lead to the development of drugs that mitigate aging and disease. This volume will therefore serve as a vital reference for all involved in the fields of sports science and medicine, as well as anyone seeking to understand the molecular mechanisms by which exercise promotes whole-body health. | ||||
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Publication Date | 2017/2017 | |||
Bibliographic Information 396 pages, illustrated (46 color and 28 B&W), index | ||||
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The Biology of Exercise |
Title The Biology of Heart Disease
Unique URL http://www.cshlpress.com/link/bioheartdis.htm | ||||
ISBN | 978-1-936113-86-6 | |||
Price | $135 | |||
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The heart is the first organ to form in a developing embryo, and all subsequent life processes depend on its proper function. But a range of genetic and environmental factors can lead to its failure. Inherited mutations give rise to congenital heart disease, the most common birth defect, and abnormalities of the adult heart are a leading cause of illness and death in industrialized countries. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine describes how recent advances in genetics, stem cell biology, and developmental biology are transforming the way we understand and treat heart disease. Contributors review the various cell lineages and molecular networks involved in heart development; the genetic basis of inherited cardiac conditions such as congenital heart disease, cardiomyopathies, and aortic aneurysm; and how various cutting-edge technologies and models are being employed to study heart biology, uncover disease-related processes, and identify therapeutic targets. Topics include tissue engineering, genome editing, stem cells, cardiomyocyte reprogramming, chemically modified RNA, and next-generation DNA sequencing. The authors also consider the process of drug discovery and development, and the potential for patient-specific treatments and therapies. This volume is a valuable reference for cardiologists, geneticists, and cell and developmental biologists interested in this complex, vital organ and the future of cardiovascular medicine. | ||||
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Publication Date | 2015/2015 | |||
Bibliographic Information 287 pages, illustrated (46 color, 3 B&W), index | ||||
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Title The Biology of Plants
Unique URL http://www.cshlpress.com/link/symp-77p.htm | ||||
ISBN | 978-1-621820-26-0 | |||
Price | $129 | |||
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Plants are integral to human well being, and many species have been domesticated for over ten thousand years. Evidence of plant scientific investigation and classification can be found in ancient texts from cultures around the world (Chinese, Indian, Greco-Roman, Muslim etc.), while early modern botany can be traced to the late 15th and early 16th centuries in Europe. During the past several decades plant biology has been revolutionized first by molecular biology and then by the genomic era. The model organism Arabidopsis thaliana has proved an invaluable tool for investigation into fundamental processes in plant biology, many of which share commonalities with animal biology. Plant-specific processes from reproduction to immunity and second messengers have also yielded to extensive investigation. With the genomes of more than thirty plant species now available and many more planned in the near future, the impact on our understanding of plant evolution and biology continues to grow. Our increased ability to engineer plant species to a variety of ends may provide novel solutions to ensure adequate and reliable food production and renewable energy even as climate change impacts our environment. The decision to focus the 2012 Symposium on plant science reflects the enormous research progress achieved in recent years, and is intended to provide a broad synthesis of the current state of the field, setting the stage for future discoveries and application. This is the first Symposium in this historic series focused exclusively on the botanical sciences. | ||||
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Publication Date | 2013/2013 | |||
Bibliographic Information 352 pp., illus. 55 4C, 102 B | ||||
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The Biology of Plants |
Title The Biology of Plants
Unique URL http://www.cshlpress.com/link/symp-77.htm | ||||
ISBN | 978-1-621820-25-3 | |||
Price | $318 | |||
Series Information: | ||||
Plants are integral to human well being, and many species have been domesticated for over ten thousand years. Evidence of plant scientific investigation and classification can be found in ancient texts from cultures around the world (Chinese, Indian, Greco-Roman, Muslim etc.), while early modern botany can be traced to the late 15th and early 16th centuries in Europe. During the past several decades plant biology has been revolutionized first by molecular biology and then by the genomic era. The model organism Arabidopsis thaliana has proved an invaluable tool for investigation into fundamental processes in plant biology, many of which share commonalities with animal biology. Plant-specific processes from reproduction to immunity and second messengers have also yielded to extensive investigation. With the genomes of more than thirty plant species now available and many more planned in the near future, the impact on our understanding of plant evolution and biology continues to grow. Our increased ability to engineer plant species to a variety of ends may provide novel solutions to ensure adequate and reliable food production and renewable energy even as climate change impacts our environment. The decision to focus the 2012 Symposium on plant science reflects the enormous research progress achieved in recent years, and is intended to provide a broad synthesis of the current state of the field, setting the stage for future discoveries and application. This is the first Symposium in this historic series focused exclusively on the botanical sciences. | ||||
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Publication Date | 2013/2013 | |||
Bibliographic Information 352 pp., illus. 55 4C, 102 B | ||||
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The Biology of Plants |
Title The Biology of the TGF-β Family
Unique URL http://www.cshlpress.com/link/bioTGF-b.htm | ||||
ISBN | 978-1-621820-36-9 | |||
Price | $135 | |||
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The transforming growth factor β (TGF-β) family is a large group of structurally related proteins that drive developmental programs and control cell behavior. The TGF-β family members exert their effects by binding to receptors on the cell surface, activating intracellular signaling pathways that modulate gene expression programs that control normal cell physiology, immune responses, and a variety of developmental processes. TGF-β signaling is also important in conditions such as cancer, skeletal disorders, and cardiovascular diseases. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive view of the different members of the TGF-β family, the signaling pathways they control, and how they influence development, normal physiology, and disease. The contributors describe the various TGF-β family ligands, including activins and bone morphogenetic proteins (BMPs), the structures and functions of the type I and type II receptors, and how ligand-receptor binding is regulated. Both Smad and non-Smad signaling pathways are discussed, as is cross talk between TGF-β and other signaling pathways (e.g., Wnt). Individual chapters are devoted to the roles of TGF-β signaling in specific biological processes, including cell proliferation, mesenchymal differentiation, branching morphogenesis, stem cell biology, immunity, vascular function, reproduction, and neurobiology. The roles of TGF-β signaling in cancer, fibrosis, skeletal diseases, and other conditions, as well as prospects for therapeutics, are also covered. The authors also review TGF-β signaling in model organisms (e.g., C. elegans and Drosophila), as well as the discovery of TGF-β and early research in the field. This volume is therefore a comprehensive reference on the biology of the TGF-β family, and it will be valuable for not only cell and developmental biologists but all who wish to learn about this important field of research. | ||||
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Publication Date | 2017/2017 | |||
Bibliographic Information 1164 pages, illustrated (149 color and 8 B&W), index | ||||
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Title Blue Skies and Bench Space: Adventures in Cancer Research
Unique URL http://www.cshlpress.com/link/blueskies.htm | ||||
ISBN | 978-1-621820-77-2 | |||
Price | $22 | |||
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What happens when a cancer research institute's only remit is to be the best it can be? For more than 100 years, one laboratory in London has operated on just that premise. With a generous budget, inspired leadership, and a stable of scientific thoroughbreds, the Imperial Cancer Research Fund Laboratories produced some of the 20th century's most exciting advances in molecular biology. In its 21st century incarnation, as the Cancer Research UK London Research Institute, it continues to inspire a new generation of researchers. r> In this book, written with the assistance of the past and present inhabitants of the London Research Institute, Kathy Weston tells the inside story of the lab's greatest voyages into the scientific unknown, revealing the personalities behind the dry passive voice of the scientific paper. Science is an art, a vocation, a complicated landscape of data in which, just sometimes, the trained and alert eye can detect a glint of gold. In these pages, the gold is present, but equally to be treasured are the all-too-human scientists stumbling towards its seductive glimmer. | ||||
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Publication Date | 2014/2014 | |||
Bibliographic Information 336 pp., illus., glossary, index | ||||
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Title Bone: A Regulator of Physiology
Unique URL not available | ||||
ISBN | 978-1-621822-20-2 | |||
Price | $135 | |||
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Bone plays far more than just a structural role in our bodies. It actively communicates with our brains, kidneys, and other organs, releasing and responding to signaling molecules that regulate biological processes such as glucose metabolism and lymphoid development. Defects in these interactions may lead to osteoporosis, multiple myeloma, and other diseases or developmental flaws. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines our current understanding of the dynamic interactions between bone and other organs and systems in the body and the molecules and mechanisms that mediate them. Contributors discuss endocrine factors that act on bone (e.g., parathyroid hormone and sex steroids) as well as molecules that are secreted by bone and act on other tissues (e.g., osteocalcin and FGF23). The interplay between bone and the nervous, immune, and vascular systems is explored, as is the influence of gut microbiota on bone homeostasis. The authors also consider the diseases that result when homeostatic pathways are disrupted and how new knowledge of these pathways may be harnessed for the development of therapeutics. This volume is therefore a valuable reference for not only physiologists and endocrinologists but for all who are interested in diseases linked to the skeletal system. | ||||
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Publication Date | 2018/2018 | |||
Bibliographic Information 232 pages, illustrated (33 color and 5 B&W), index | ||||
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Title Brains & Behavior: Order and Disorder in the Nervous System
Unique URL not available | ||||
ISBN | 978-1-621823-36-0 | |||
Price | $129 | |||
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The 2018 Symposium on Brains & Behavior: Order & Disorder in the Nervous System explores the tremendous recent progress in neuroscience and technologies and how these advances may be used to improve brain health and address psychiatric and neurological disorders. | ||||
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Publication Date | 2019/2019 | |||
Bibliographic Information 302 pages, illustrated (92 color and 68 B&W), index | ||||
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Title Brains & Behavior: Order and Disorder in the Nervous System
Unique URL not available | ||||
ISBN | 978-1-621823-35-3 | |||
Price | $318 | |||
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The 2018 Symposium on Brains & Behavior: Order & Disorder in the Nervous System explores the tremendous recent progress in neuroscience and technologies and how these advances may be used to improve brain health and address psychiatric and neurological disorders. | ||||
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Publication Date | 2019/2019 | |||
Bibliographic Information 302 pages, illustrated (92 color and 68 B&W), index | ||||
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Title Budding Yeast: A Laboratory Manual
Unique URL http://www.cshlpress.com/link/buddingyeastp.htm | ||||
ISBN | 978-1-621820-56-7 | |||
Price | $90 | |||
Series Information: | ||||
Over the past century, studies of the budding yeast Saccharomyces cerevisiae have helped to unravel principles of nearly every aspect of eukaryotic cell biology—from metabolism and molecular genetics to cell division and differentiation. Thanks to its short generation time, ease of genetic manipulation, and suitability for high-throughput studies, yeast remains the focus of research in a vast number of laboratories worldwide. This laboratory manual provides a comprehensive collection of experimental procedures that continue to make budding yeast an informative model. The contributors describe methods for culturing and genetically modifying yeast, strategies and tools (e.g., gene deletion collections) for functional analyses, approaches for characterizing cell structure and morphology, and techniques to probe the modifications and interactions of various cellular constituents (e.g., using one- and two-hybrid screens). Strategies for studying metabolomics, complex traits, and evolution in yeast are also covered, as are methods to isolate and investigate new strains of yeast from the wild. Several additional chapters are devoted to bioinformatics tools and resources for yeast biology (e.g., the Saccharomyces Genome Database). This manual is therefore an essential resource for all researchers, from graduate level upward, who use budding yeast to explore the intricate workings of cells. | ||||
Editor
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Publication Date | 2016/2016 | |||
Bibliographic Information 710 pages, illustrated (72 color, 24 B&W), index | ||||
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Related Products |
Budding Yeast: A Laboratory Manual |
Title Budding Yeast: A Laboratory Manual
Unique URL http://www.cshlpress.com/link/buddingyeast.htm | ||||
ISBN | 978-1-621820-55-0 | |||
Price | $150 | |||
Series Information: | ||||
Over the past century, studies of the budding yeast Saccharomyces cerevisiae have helped to unravel principles of nearly every aspect of eukaryotic cell biology—from metabolism and molecular genetics to cell division and differentiation. Thanks to its short generation time, ease of genetic manipulation, and suitability for high-throughput studies, yeast remains the focus of research in a vast number of laboratories worldwide. This laboratory manual provides a comprehensive collection of experimental procedures that continue to make budding yeast an informative model. The contributors describe methods for culturing and genetically modifying yeast, strategies and tools (e.g., gene deletion collections) for functional analyses, approaches for characterizing cell structure and morphology, and techniques to probe the modifications and interactions of various cellular constituents (e.g., using one- and two-hybrid screens). Strategies for studying metabolomics, complex traits, and evolution in yeast are also covered, as are methods to isolate and investigate new strains of yeast from the wild. Several additional chapters are devoted to bioinformatics tools and resources for yeast biology (e.g., the Saccharomyces Genome Database). This manual is therefore an essential resource for all researchers, from graduate level upward, who use budding yeast to explore the intricate workings of cells. | ||||
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Publication Date | 2016/2016 | |||
Bibliographic Information 710 pages, illustrated (72 color, 24 B&W), index | ||||
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Related Products |
Budding Yeast: A Laboratory Manual |
Title C. elegans Atlas
Unique URL http://www.cshlpress.com/link/celatlash.htm | ||||
ISBN | 978-087969794-5 | |||
Price | $179.00 | |||
Series Information: | ||||
Derived from the acclaimed online “WormAtlas,” C. elegans Atlas is a large-format, full-color atlas of the hermaphroditic form of the model organism C. elegans, known affectionately as “the worm” by workers in the field. Prepared by the editors of the WormAtlas Consortium, David H. Hall and Zeynep F. Altun, this book combines explanatory text with copious, labeled, color illustrations and electron micrographs of the major body systems of C. elegans. Also included are electron microscopy cross sections of the worm. This laboratory reference is essential for the working worm biologist, at the bench and at the microscope, and provides a superb companion to the C. elegans II monograph. It is also a valuable tool for investigators in the fields of developmental biology, neurobiology, reproductive biology, gene expression, and molecular biology. | ||||
Author
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Publication Date | 2008/2008 | |||
Bibliographic Information 348 pp., illus., appendix, index | ||||
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Related Products |
C. elegans Atlas The Nematode Caenorhabditis elegans C. elegans II |
Title C. elegans Atlas
Unique URL http://www.cshlpress.com/link/celatlas.htm | ||||
ISBN | 978-087969715-0 | |||
Price | $128.00 | |||
Series Information: | ||||
Derived from the acclaimed online “WormAtlas,” C. elegans Atlas is a large-format, full-color atlas of the hermaphroditic form of the model organism C. elegans, known affectionately as “the worm” by workers in the field. Prepared by the editors of the WormAtlas Consortium, David H. Hall and Zeynep F. Altun, this book combines explanatory text with copious, labeled, color illustrations and electron micrographs of the major body systems of C. elegans. Also included are electron microscopy cross sections of the worm. This laboratory reference is essential for the working worm biologist, at the bench and at the microscope, and provides a superb companion to the C. elegans II monograph. It is also a valuable tool for investigators in the fields of developmental biology, neurobiology, reproductive biology, gene expression, and molecular biology. | ||||
Author
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Publication Date | 2008/2008 | |||
Bibliographic Information 348 pp., illus., appendix, index | ||||
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Related Products |
C. elegans Atlas The Nematode Caenorhabditis elegans C. elegans II |
Title C. elegans II
Unique URL http://www.cshlpress.com/link/celegans.htm | ||||
ISBN | 978-087969532-3 | |||
Price | $85 | |||
Series Information: | ||||
Studies of the cells and genes of the nematode C. elegans have become a cornerstone of current biology. A classic 1988 Cold Spring Harbor monograph, The Nematode Caenorhabditis elegans, described the basic genetics, anatomy and development of the organism. Now, in that authoritative tradition, comes C. elegans II -- not a second edition but a book that breaks new ground and defines the current status of the field, providing a detailed molecular explanation of how development is regulated and the nervous system specifies varied aspects of behavior. This volume is a must for any investigator doing worm studies but it has been written and rigorously edited to illuminate for a wider community of investigators in cell and molecular biology who should know how new knowledge of C. elegans relates to their own specialty. | ||||
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Publication Date | February 1997/1997 | |||
Bibliographic Information 1222 pp., illus., color plates, index | ||||
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Related Products |
The Nematode Caenorhabditis elegans C. elegans Atlas |
Title Calcium Signaling, Second Edition
Unique URL http://www.cshlpress.com/link/calsignaling2.htm | ||||
ISBN | 978-1-621822-92-9 | |||
Price | $135 | |||
Series Information: | ||||
Calcium signals—rapid changes in calcium ion concentration—are carefully orchestrated by a suite of proteins that transport and bind to calcium ions inside cells. These signals influence virtually all aspects of animal development and physiology, from fertilization and cell differentiation to muscle contraction and nerve impulses. Aberrant calcium signaling is associated with various pathologies (e.g., cancer and neurodegeneration) as well as aging. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on major facets of calcium signaling. The contributors discuss the components and activities of the various calcium-sequestering organelles inside cells, the dynamic interactions that lead to spatiotemporally distinct signals in different circumstances, and the downstream effector mechanisms that translate the signals into biological outcomes. Recent advances in the field (e.g., structural insights into the functions of certain calcium channels) are emphasized throughout. The authors also discuss normal and perturbed calcium signaling during fertilization, development, physiology, regeneration, aging, and disease. This volume is therefore an indispensable reference for biochemists, cell and developmental biologists, and physiologists seeking a comprehensive treatment of calcium signaling. | ||||
Editor
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Publication Date | 2019/2019 | |||
Bibliographic Information 568 pages, illustrated (108 color and 2 B&W), index | ||||
Set Info | ||||
Topics |
Title Calcium Techniques: A Laboratory Manual
Unique URL http://www.cshlpress.com/link/calciumtech.htm | ||||
ISBN | 978-1-621820-78-9 | |||
Price | $150 | |||
Series Information: | ||||
Life begins with a surge of calcium ions (Ca2+) at fertilization, and thereafter, Ca2+ signaling influences nearly every aspect of mammalian development and physiology, from gene expression and cell proliferation to muscle contraction and nerve impulses. To create spatiotemporally distinct Ca2+ signals, cells use a variety of mechanisms to recognize, transport, and buffer Ca2+. Thus, a diverse range of reliable experimental techniques is necessary to study the movement of Ca2+ and the various effectors involved. This laboratory manual provides step-by-step protocols for studying many facets of Ca2+ signaling, as well as background information on the principles and applications of the techniques. Contributors discuss how to use fluorescent, luminescent, and genetically encoded Ca2+ probes in conjunction with state-of-the-art imaging modalities to characterize Ca2+ signals. Electrophysiological measurements of Ca2+ channel activity are described, as are radioactive Ca2+ flux assays and methods to investigate signaling mediated by specific Ca2+-mobilizing messengers (IP3, cADPR, and NAADP). Techniques to modulate and suppress intra- and intercellular signals are also provided. Each protocol is complete with a list of required materials, detailed recipes for media and reagents, and troubleshooting advice. Specific chapters are devoted to Ca2+ signaling techniques in nonmammalian systems, such as plants, yeast, zebrafish, and Xenopus. Methods for assessing Ca2+-binding kinetics and strategies for developing mathematical models of Ca2+ signaling are also included. Thus, this manual is a comprehensive laboratory resource for biochemists, cell and developmental biologists, and physiologists who are using or looking to expand their repertoire of Ca2+ techniques. | ||||
Editor
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Publication Date | 2014/2014 | |||
Bibliographic Information 608 pp., illus. (62 4C, 56 B&W), index | ||||
Set Info | ||||
Topics |
Title Calcium Techniques: A Laboratory Manual
Unique URL http://www.cshlpress.com/link/calciumtechp.htm | ||||
ISBN | 978-1-936113-58-3 | |||
Price | $95 | |||
Series Information: | ||||
Life begins with a surge of calcium ions (Ca2+) at fertilization, and thereafter, Ca2+ signaling influences nearly every aspect of mammalian development and physiology, from gene expression and cell proliferation to muscle contraction and nerve impulses. To create spatiotemporally distinct Ca2+ signals, cells use a variety of mechanisms to recognize, transport, and buffer Ca2+. Thus, a diverse range of reliable experimental techniques is necessary to study the movement of Ca2+ and the various effectors involved. This laboratory manual provides step-by-step protocols for studying many facets of Ca2+ signaling, as well as background information on the principles and applications of the techniques. Contributors discuss how to use fluorescent, luminescent, and genetically encoded Ca2+ probes in conjunction with state-of-the-art imaging modalities to characterize Ca2+ signals. Electrophysiological measurements of Ca2+ channel activity are described, as are radioactive Ca2+ flux assays and methods to investigate signaling mediated by specific Ca2+-mobilizing messengers (IP3, cADPR, and NAADP). Techniques to modulate and suppress intra- and intercellular signals are also provided. Each protocol is complete with a list of required materials, detailed recipes for media and reagents, and troubleshooting advice. Specific chapters are devoted to Ca2+ signaling techniques in nonmammalian systems, such as plants, yeast, zebrafish, and Xenopus. Methods for assessing Ca2+-binding kinetics and strategies for developing mathematical models of Ca2+ signaling are also included. Thus, this manual is a comprehensive laboratory resource for biochemists, cell and developmental biologists, and physiologists who are using or looking to expand their repertoire of Ca2+ techniques. | ||||
Editor
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Publication Date | 2014/2014 | |||
Bibliographic Information 608 pp., illus. (62 4C, 56 B&W), index | ||||
Set Info | ||||
Topics |
Title Cancer Evolution
Unique URL http://www.cshlpress.com/link/cancerevo.htm | ||||
ISBN | 978-1-621821-43-4 | |||
Price | $135 | |||
Series Information: | ||||
Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer. | ||||
Editor
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Publication Date | 2017/2017 | |||
Bibliographic Information 304 pages, illustrated (62 color and 5 B&W), index | ||||
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Topics |
Title Career Opportunities in Biotechnology and Drug Development
Unique URL not available | ||||
ISBN | 978-0-879698-80-5 | |||
Price | $40.00 | |||
Series Information: | ||||
As the world of biotechnology has grown in leaps and bounds, so too have the career opportunities. But the choices can be daunting. What types of jobs are available? How do you get your foot in the door? What will your job entail if you become a “Preclinical Project Manager” or a “Process Scientist”? What's the difference between biotech and pharma? Career Opportunities in Biotechnology and Drug Development provides a comprehensive and systematic overview of careers in the life science industry, with all their ups and downs. The author, Toby Freedman, Ph.D., has conducted interviews with hundreds of key players in the industry, who provide first–hand explanations of their day–to–day roles and responsibilities, and offer key insights into how they landed those jobs in the first place. Careers in everything from discovery research to venture capital are covered in detail. Each chapter includes valuable sections on preparing yourself for a prospective career: educational requirements and personality characteristics needed; recommendations of books, magazines, and Web site resources; and issues to consider regarding salary and compensation. The book also includes interviewing and job searching tips, as well as suggestions on writing a resume specifically for industry. Career Opportunities in Biotechnology and Drug Development is an essential guide for science graduates and medical, business, legal, high–tech or engineering professionals. With discussions of job security, future trends, and potential career paths, even those already working in industry will find helpful information on how to take advantage of opportunities available within their own companies and elsewhere. This book will help you make wiser and more informed decisions about what role you would like to play in the biotechnology and drug development industry. | ||||
Author
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Publication Date | 2009/2009 | |||
Bibliographic Information 409 pp., illus., index | ||||
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Topics |
Title Career Opportunities in Biotechnology and Drug Development
Unique URL http://www.cshlpress.com/link/careerp.htm | ||||
ISBN | 978-0-879698-80-5 | |||
Price | $46.00 | |||
Series Information: | ||||
As the world of biotechnology has grown in leaps and bounds, so too have the career opportunities. But the choices can be daunting. What types of jobs are available? How do you get your foot in the door? What will your job entail if you become a “Preclinical Project Manager” or a “Process Scientist”? What's the difference between biotech and pharma? Career Opportunities in Biotechnology and Drug Development provides a comprehensive and systematic overview of careers in the life science industry, with all their ups and downs. The author, Toby Freedman, Ph.D., has conducted interviews with hundreds of key players in the industry, who provide first–hand explanations of their day–to–day roles and responsibilities, and offer key insights into how they landed those jobs in the first place. Careers in everything from discovery research to venture capital are covered in detail. Each chapter includes valuable sections on preparing yourself for a prospective career: educational requirements and personality characteristics needed; recommendations of books, magazines, and Web site resources; and issues to consider regarding salary and compensation. The book also includes interviewing and job searching tips, as well as suggestions on writing a resume specifically for industry. Career Opportunities in Biotechnology and Drug Development is an essential guide for science graduates and medical, business, legal, high–tech or engineering professionals. With discussions of job security, future trends, and potential career paths, even those already working in industry will find helpful information on how to take advantage of opportunities available within their own companies and elsewhere. This book will help you make wiser and more informed decisions about what role you would like to play in the biotechnology and drug development industry. | ||||
Author
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Publication Date | 2009/2009 | |||
Bibliographic Information 409 pp., illus., index | ||||
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Career Opportunities in Biotechnology and Drug Development At the Helm: A Laboratory Navigator |
Title Career Options for Biomedical Scientists
Unique URL http://www.cshlpress.com/link/CareerOpsBioSci.htm | ||||
ISBN | 978-1-936113-72-9 | |||
Price | $50 | |||
Series Information: | ||||
Most people who do a PhD and postdoctoral work in the biomedical sciences do not end up as principal investigators in a research lab. Despite this, graduate courses and postdoctoral fellowships tend to focus almost exclusively on training for bench science rather than other career paths. This book plugs the gap by providing information about a wide variety of different careers that individuals with a PhD in the life sciences can pursue. Covering everything from science writing and grant administration to patent law and management consultancy, the book includes firsthand accounts of what the jobs are like, the skills required, and advice on how to get a foot in the door. It will be a valuable resource for all life scientists considering their career options and laboratory heads who want to give career advice to their students and postdocs. | ||||
Editor
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Publication Date | 2015/2015 | |||
Bibliographic Information 232pp., illus. (13 B&W), index Buy 10-19 copies—25% off | ||||
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Topics |
Title Cell Biology of Addiction
Unique URL http://www.cshlpress.com/link/celbioad.htm | ||||
ISBN | 978-087969753-2 | |||
Price | $129 | |||
Series Information: | ||||
This monograph, written by experts in the field, is devoted to the molecular analysis of addiction pathways in the brain. It provides an intensive overview of the fundamentals, state–of–the–art advances, and major gaps in the cell and molecular biology of drug addiction within the broader context of neuroscience. Addiction research is a branch of neuroscience and psychology. The emphasis in this book is on hard science and the market for it will be found among research investigators and grad students within the field of neuroscience. The research presented is not only applicable to the study of drug abuse and addiction, but has clear implications for clarifying mechanisms of learning and memory, neuroadaptation, perception, volitional behavior, motivation, reward, and other disciplines of neuroscience. | ||||
Editor
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Publication Date | 2006/2006 | |||
Bibliographic Information 465 pp., illus., appendices, index | ||||
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Topics |
Title Cell Death Techniques: A Laboratory Manual
Unique URL http://www.cshlpress.com/link/celldeathtech.htm | ||||
ISBN | 978-1-621820-12-3 | |||
Price | $150 | |||
Series Information: | ||||
Regulated cell death, which is involved in nearly every aspect of animal development and physiology, can be challenging to study in the laboratory. There are multiple types of cell death, several interconnected signaling pathways can be activated, and the postmortem consequences may vary. Therefore, a combination of specialized techniques is often required to characterize and confirm cell death in the system of interest. This laboratory manual provides a comprehensive suite of step-by-step protocols for inducing, detecting, visualizing, characterizing, and quantifying cell death in a variety of systems. The contributors describe strategies for identifying and evaluating the biochemical and morphological changes that occur during apoptosis, autophagy, necrosis, and other forms of cell death, as well as for pinpointing the genes and proteins that may be involved. The protocols employ flow cytometry, imaging and microscopy, RNAi, western blotting, enzymatic activity measurements, and other tools to assess phenomena such as DNA fragmentation, lysosomal membrane permeabilization, autophagic flux, apoptosome or ripoptosome formation, caspase activation, and cytochrome c release. Techniques are described for both in vitro systems and in vivo models, including mice, C. elegans, and Drosophila. The authors also provide guidance on interpreting and presenting the results of cell death experiments, as well as advice on complementary procedures that may be required to confirm the results of a given experiment. This indispensable laboratory resource will enable all cell and developmental biologists, from the graduate level upward, to confidently carry out and comprehend a wide array of cell viability assays. | ||||
Editor
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Publication Date | 2015/2015 | |||
Bibliographic Information 514 pages, illustrated (54 color, 73 B&W), index | ||||
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Related Products |
Cell Death Techniques: A Laboratory Manual |
Title Cell Death Techniques: A Laboratory Manual
Unique URL http://www.cshlpress.com/link/celldeathtechp.htm | ||||
ISBN | 978-1-621820-05-5 | |||
Price | $95 | |||
Series Information: | ||||
Regulated cell death, which is involved in nearly every aspect of animal development and physiology, can be challenging to study in the laboratory. There are multiple types of cell death, several interconnected signaling pathways can be activated, and the postmortem consequences may vary. Therefore, a combination of specialized techniques is often required to characterize and confirm cell death in the system of interest. This laboratory manual provides a comprehensive suite of step-by-step protocols for inducing, detecting, visualizing, characterizing, and quantifying cell death in a variety of systems. The contributors describe strategies for identifying and evaluating the biochemical and morphological changes that occur during apoptosis, autophagy, necrosis, and other forms of cell death, as well as for pinpointing the genes and proteins that may be involved. The protocols employ flow cytometry, imaging and microscopy, RNAi, western blotting, enzymatic activity measurements, and other tools to assess phenomena such as DNA fragmentation, lysosomal membrane permeabilization, autophagic flux, apoptosome or ripoptosome formation, caspase activation, and cytochrome c release. Techniques are described for both in vitro systems and in vivo models, including mice, C. elegans, and Drosophila. The authors also provide guidance on interpreting and presenting the results of cell death experiments, as well as advice on complementary procedures that may be required to confirm the results of a given experiment. This indispensable laboratory resource will enable all cell and developmental biologists, from the graduate level upward, to confidently carry out and comprehend a wide array of cell viability assays. | ||||
Editor
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Publication Date | 2015/2015 | |||
Bibliographic Information 514 pages, illustrated (54 color, 73 B&W), index | ||||
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Related Products |
Cell Death Techniques: A Laboratory Manual |
Title Cell Death: Apoptosis and Other Means to an End, Second Edition
Unique URL http://www.cshlpress.com/link/celldeath2p.htm | ||||
ISBN | 978-1-621822-14-1 | |||
Price | $46 | |||
Series Information: | ||||
A million cells in our bodies die every second—they commit suicide by activating a process called apoptosis or other forms of programmed cell death. These mechanisms are essential for survival of the body as a whole and play critical roles in various developmental processes, the immune system, and cancer. In this second edition of Douglas Green’s essential book on cell death, Green retains the bottom-up approach of the first edition, starting with the enzymes that carry out the execution (caspases) and their cellular targets before examining the machinery that connects them to signals that cause cell death. He also describes the roles of cell death in development, neuronal selection, and the development of self-tolerance in the immune system, as well as how the body uses cell death to defend against cancer. The new edition is fully updated to cover the many recent advances in our understanding of the death machinery and signals that control cell death. These include the mechanisms regulating necroptosis, mitophagy, and newly identified processes, such as ferroptosis. The book will thus be of great interest to researchers actively working in the field, as well as biologists and undergraduates encountering the topic for the first time. | ||||
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Publication Date | 2018/2018 | |||
Bibliographic Information 278 pages, illustrated (170 color and 50 B&W), index | ||||
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Related Products |
Cell Death: Apoptosis and Other Means to an End, Second Edition |
Title Cell Growth: Control of Cell Size
Unique URL http://www.cshlpress.com/link/cellgrow.htm | ||||
ISBN | 978-087969672-6 | |||
Price | $139 | |||
Series Information: | ||||
Recent breakthroughs in the field of cell growth, particularly in the control of cell size, are reviewed by experts in the three major divisions of the field: growth of individual cells, growth of organs, and regulation of cell growth in the contexts of development and cell division. This book is an introductory overview of the field and should be adaptable as a textbook. | ||||
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Publication Date | 2004/2004 | |||
Bibliographic Information 652 pp., illus., appendices, index | ||||
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Topics |
Title Cell Polarity
Unique URL http://www.cshlpress.com/link/cellpolarity.htm | ||||
ISBN | 978-1-621821-45-8 | |||
Price | $135 | |||
Series Information: | ||||
Most animal cells are polarized, with structurally and functionally distinct regions. This polarization facilitates processes such as differentiation and morphogenesis, directional cell migration, nerve impulse transmission, and transport of molecules across tissues. The dysregulation of these processes can lead to developmental disorders and is a feature of many cancers. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews our understanding of the molecular mechanisms involved in establishing and maintaining cell polarity, as well as their relevance for human disorders. Contributors discuss how cells coordinate signaling pathways, membrane trafficking, and cytoskeletal remodeling to ensure proper spatial arrangement of cellular components. Processes such as transcytosis, exocyst-mediated vesicle trafficking, and endosomal sorting are covered in detail. Throughout, the focus is on epithelial cells and how polarity mechanisms facilitate the development of their apical and basolateral surfaces, tube formation (e.g., in blood vessel development), exchange of waste and nutrients, and the generation and maintenance of specialized structures at the cell surface (e.g., cilia). The authors also describe the polarity mechanisms involved in collective cell migration, a phenomenon seen during morphogenesis and cancer metastasis. This volume will thus be essential reading for all cell and developmental biologists, as well as those interested in how cell polarity processes impact human health and disease. | ||||
Editor
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Publication Date | 2017/2017 | |||
Bibliographic Information 312 pages, illustrated (42 color, 10 B&W), index | ||||
Set Info | ||||
Topics |
Title Cell Survival and Cell Death, Second Edition
Unique URL not available | ||||
ISBN | 978-1-621823-55-1 | |||
Price | $135 | |||
Series Information: | ||||
In multicellular organisms, cell death is required for normal development, homeostasis, and the elimination of infected or injured cells. The mechanisms by which cell death occurs are genetically encoded and carefully controlled. Perturbations that enhance or suppress cell death may lead to cancer, neurodegeneration, and inflammatory diseases. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on the cell signaling that underlies the main cell death programs (apoptosis, pyroptosis, and necroptosis) and how this knowledge is driving the development of therapeutic drugs to treat some human diseases. Contributors describe in detail the molecular mechanisms of cell death signaling and the myriad players involved, including death receptor–ligand systems, BCL-2 family proteins, caspases, inflammasomes, gasdermin, MLKL, RIPK1, A20, and XIAP. They also examine the involvement of cell death programs in various pathologies and the therapeutic potential of inhibiting key pathway components. Chapters are additionally devoted to cell death signaling mechanisms in plants and lower organisms, as well as the evolution of those mechanisms and the influence of pathogens that seek to evade them. This volume is therefore an essential reference for cell and developmental biologists, cancer biologists, and all who wish to explore recent progress in our understanding of cell death programs. | ||||
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Publication Date | 2020/2020 | |||
Bibliographic Information 310 pages, illustrated (61 color), index | ||||
Set Info | ||||
Topics |
Title Cell-Cell Junctions, Second Edition
Unique URL not available | ||||
ISBN | 978-1-621821-51-9 | |||
Price | $135 | |||
Series Information: | ||||
Neighboring cells are linked to each other by multimolecular complexes such as adherens junctions, desmosomes, and gap junctions. These complexes help maintain tissue integrity, act as barriers to permeability, reinforce cell polarity, and allow cells to communicate with each other. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews our understanding of the organization, regulation, and dynamics of cell–cell junctions and the roles they play in morphogenesis, tissue homeostasis, and disease. The contributors examine the assembly and structure of different cell–cell adhesion systems, the plasticity of cell–cell junctions (e.g., during cell migration), and how the junctions act as hubs to sense and transduce various mechanical and chemical signals. The authors also discuss the roles of cell–cell junctions in specific developmental and physiological processes, such as hearing, skeletal myogenesis, and neural circuit assembly, as well as in diseases such as cancer. This volume is therefore an indispensable reference for cell and developmental biologists, as well as anyone interested in understanding the roles of these complexes in human health and disease. | ||||
Editor
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Publication Date | 2017/2017 | |||
Bibliographic Information 374 pages, illustrated (60 color and 2 B&W), index | ||||
Set Info | ||||
Topics |
Title Chromatin Deregulation in Cancer
Unique URL http://www.cshlpress.com/link/cancerchromatin.htm | ||||
ISBN | 978-1-621821-40-3 | |||
Price | $135 | |||
Series Information: | ||||
The human genome is packaged into chromatin, which is composed of numerous proteins that help control gene expression, DNA replication and repair, and genome stability. In recent years, it has become clear that the deregulation of chromatin structure plays an important role in numerous cancers. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the chromatin components that are commonly mutated, what is understood about the mechanisms that lead to hematological malignancies and solid tumors, and prospects for the therapeutic modulation of chromatin. The contributors describe how histone proteins, histone-modifying enzymes, chromatin remodelers, transcriptional regulatory complexes, enhancer-associated factors, and signaling proteins are dysregulated in cancer pathogenesis. In addition, the roles of DNA methylation and noncoding RNAs are covered. The authors also discuss small molecules and other drugs that are currently under development or already used to treat cancer (e.g., HDAC inhibitors and DNA hypomethylating agents). This book is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists interested in understanding cancer therapies. | ||||
Editor
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Publication Date | 2017/2017 | |||
Bibliographic Information 382 pages, illustrated (54 color, 10 B&W), index | ||||
Set Info | ||||
Topics |
Title Chromosome Segregation and Structure
Unique URL not available | ||||
ISBN | 978-1-621822-87-5 | |||
Price | $129 | |||
Series Information: | ||||
The 82nd Cold Spring Harbor Symposium focused on Chromosome Segregation & Structure and addressed the enormous progress in our understanding of the nature and behavior of chromosomes during the life cycle of the cell. It is rare to find such a wide-ranging perspective on this topic in one volume and this collection of papers will be valuable to investigators interested in many aspects of cell biology, genetics, and cancer. The topics covered at the meeting included Meiosis; Mitosis; Chromosome Segregation; Centrosomes and Centrioles; Ploidy, Chromosome Segregation Errors, and Disease; Asymmetric Cell Division; Nuclear Architecture; Chromosome Structure and Condensation; Sister Chromatid Cohesion; Genome Stability; and Germ Cells. Numerous speakers participated in interviews during the course of the Symposium week and transcripts of those discussions and the Dorcas Cummings lecture by David Page are included. | ||||
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Publication Date | 2018/2018 | |||
Bibliographic Information 426 pages, illustrated (136 color and 64 B&W), index | ||||
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Title Chromosome Segregation and Structure
Unique URL not available | ||||
ISBN | 978-1-621822-86-8 | |||
Price | $318 | |||
Series Information: | ||||
The 82nd Cold Spring Harbor Symposium focused on Chromosome Segregation & Structure and addressed the enormous progress in our understanding of the nature and behavior of chromosomes during the life cycle of the cell. It is rare to find such a wide-ranging perspective on this topic in one volume and this collection of papers will be valuable to investigators interested in many aspects of cell biology, genetics, and cancer. The topics covered at the meeting included Meiosis; Mitosis; Chromosome Segregation; Centrosomes and Centrioles; Ploidy, Chromosome Segregation Errors, and Disease; Asymmetric Cell Division; Nuclear Architecture; Chromosome Structure and Condensation; Sister Chromatid Cohesion; Genome Stability; and Germ Cells. Numerous speakers participated in interviews during the course of the Symposium week and transcripts of those discussions and the Dorcas Cummings lecture by David Page are included. | ||||
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Publication Date | 2018/2018 | |||
Bibliographic Information 426 pages, illustrated (136 color and 64 B&W), index | ||||
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Title Cilia
Unique URL http://www.cshlpress.com/link/CiliaFlagella.htm | ||||
ISBN | 978-1-621821-41-0 | |||
Price | $135 | |||
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Nearly every cell in the human body has one or more protrusive structures called cilia or flagella. These power cell movement and fluid flow, sense the extracellular environment, coordinate cell signaling, and establish left-right asymmetry during development. Mutations in genes that encode cilia can lead to disorders known as ciliopathies. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines key aspects of ciliary biology—from the molecular to the organismal level—in normal physiology and disease. The contributors dissect the complex structures of motile and nonmotile (primary) cilia, discuss how the intraflagellar transport machinery moves cargo across the central axoneme, and review how the ciliary gate controls the composition of cilia and flagella. The roles of cilia in coordinating cellular responses to environmental stimuli via cell signaling pathways (e.g., Hedgehog) are also covered, as are physiological functions in processes such as fertilization, mucociliary clearance, and vision. The authors also survey the wide spectrum of ciliopathies, describing their genetic bases, pathogenic mechanisms, and clinical manifestations. This volume is therefore an indispensable reference for all cell and developmental biologists, as well as medical geneticists and clinical scientists wishing to understand and treat disorders involving ciliary dysfunction. | ||||
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Publication Date | 2017/2017 | |||
Bibliographic Information 387 pages, illustrated (57 color and 10 B&W), index | ||||
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Title Circadian Rhythms
Unique URL http://www.cshlpress.com/link/circar.htm | ||||
ISBN | 978-1-621821-24-3 | |||
Price | $135 | |||
Series Information: | ||||
Our daily routines and physiological functions—and those of virtually all living organisms—are synchronized with the Earth's rotation about its axis. These include sleep patterns, hormone secretion, blood pressure, body temperature, and feeding behavior. Oscillations in these processes, or circadian rhythms, are controlled by molecular feedback loops that integrate with environmental and metabolic stimuli. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the molecular and cellular details of the oscillatory machinery and how they control aspects of our physiology. Contributors discuss the cell-autonomous generation of circadian time and how those mechanisms interact with circuit-level mechanisms in the suprachiasmatic nucleus. Links between circadian and redox systems, as well as the relationship between circadian oscillations and pathogenic infections, are also covered. In addition, the authors examine circadian rhythms in other species (e.g., plants and Drosophila) and how they enable the organisms to adapt to their environments. This volume will therefore serve as a valuable reference for not only neurobiologists and cell and molecular biologists, but all who wish to understand the clocks and rhythms of life. | ||||
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Publication Date | 2018/2018 | |||
Bibliographic Information 223 pages, illustrated (24 color and 10 B&W), index | ||||
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Title Clocks and Rhythms
Unique URL http://www.cshlpress.com/link/clocks.htm | ||||
ISBN | 978-087969822-5 | |||
Price | $310 | |||
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Based on presentations by world-renowned investigators at the 72nd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in biological clocks and rhythms. Topics include genetic and cellular studies aimed at characterizing circadian mechanisms; systems approaches to understanding physiological, endocrine, and neural networks; and models used for studying mental and physical cycles. A variety of normal and abnormal chronobiological patterns are discussed, including sleep, aging, migration, hibernation, seasonality, depression, and arrhythmias. | ||||
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Publication Date | 2007/2007 | |||
Bibliographic Information 674 pp., illus., indexes | ||||
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Clocks and Rhythms |
Title Cognition
Unique URL http://www.cshlpress.com/link/cognition.htm | ||||
ISBN | 978-1-621821-27-4 | |||
Price | $129 | |||
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The Proceedings of the 79th Symposium capture many of the tremendous discoveries currently being made by neuroscientists and psychologists working on cognitive processes at scales varying from the molecular to circuit to whole-brain and theoretical studies. Major advances in understanding cognitive function, including learning, memory, language, and decision-making, are being made through the application of powerful new techniques and approaches. The scientific results discussed in this volume shed light on many areas of normal brain function but also offer novel insights into the treatment of psychiatric, neurological, and neurodegenerative diseases. This volume includes state-of-the-art neurobiological research at genetic, molecular, cellular, circuit, and whole brain resolution. Additional chapters address computational neuroscience, behavioral and psychophysical studies, and evolutionary/comparative neuroscience. The Conversations included in this volume are based on interviews conducted during the Symposium and offer a broader anecdotal perspective on this fascinating subject by many of the world's leading cognitive neuroscientists. The Symposium Proceedings provides an integrative overview of the current state of the field as well as a glimpse into the emerging connections between molecular/cellular/circuit mechanisms and higher brain function by leading authorities in the field. | ||||
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Publication Date | 2015/2015 | |||
Bibliographic Information 308 pages, illustrated (111 color, 116 B&W), index | ||||
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Cognition |
Title Cognition
Unique URL http://www.cshlpress.com/link/cognitionhc.htm | ||||
ISBN | 978-1-621821-26-7 | |||
Price | $318 | |||
Series Information: | ||||
The Proceedings of the 79th Symposium capture many of the tremendous discoveries currently being made by neuroscientists and psychologists working on cognitive processes at scales varying from the molecular to circuit to whole-brain and theoretical studies. Major advances in understanding cognitive function, including learning, memory, language, and decision-making, are being made through the application of powerful new techniques and approaches. The scientific results discussed in this volume shed light on many areas of normal brain function but also offer novel insights into the treatment of psychiatric, neurological, and neurodegenerative diseases. This volume includes state-of-the-art neurobiological research at genetic, molecular, cellular, circuit, and whole brain resolution. Additional chapters address computational neuroscience, behavioral and psychophysical studies, and evolutionary/comparative neuroscience. The Conversations included in this volume are based on interviews conducted during the Symposium and offer a broader anecdotal perspective on this fascinating subject by many of the world's leading cognitive neuroscientists. The Symposium Proceedings provides an integrative overview of the current state of the field as well as a glimpse into the emerging connections between molecular/cellular/circuit mechanisms and higher brain function by leading authorities in the field. | ||||
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Publication Date | 2015/2015 | |||
Bibliographic Information 308 pages, illustrated (111 color, 116 B&W), index | ||||
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Cognition |
Title Cold Spring Harbor Monograph Archive
Unique URL not available | ||||
ISBN | 978-087969-941-3 | |||
Price | $3000 | |||
Series Information: | ||||
The Cold Spring Harbor Monograph Archive is the complete collection of scholarly monographs published by Cold Spring Harbor Laboratory Press from 1970 to 2009. The archive's 59 full-text volumes provide the life science community with definitive reviews of progress in areas of molecular, cell, and developmental biology, genetics, evolutionary biology, neuroscience, cancer biology, and molecular pathology. Each text is written and commissioned by foremost researchers in their particular discipline. The archive is an unmatched resource for its breadth of coverage in key topics and provides an in-depth account of developments as they occurred in numerous fields | ||||
Publication Date | October/2009 | |||
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Title Combining Human Genetics and Causal Inference to Understand Human Disease and Development
Unique URL not available | ||||
ISBN | 978-1-621823-81-0 | |||
Price | $135 | |||
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In human genetics, causal inference methods leverage large omics data sets and phenotypic information to decipher various cause-and-effect relationships in human health and disease (e.g., alcohol intake and hyptertension). The focus of such work is typically on modifiable variables (e.g., behavior or environmental exposure) that impact disease onset, progression, and outcome. A better understanding of these variables can lead to interventions and therapeutics that have a desirable impact on public health. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines advances in causal inference approaches in human genetics and how they are being used to enhance our understanding of human development and disease. The contributors discuss family-based study designs for causal inference, including twin designs, adoption designs, and in vitro fertilization designs, that separate inherited factors from perinatal environmental exposures. They also review various forms of Mendelian randomization—a population-based approach that is growing in utility and popularity—as well as their integration with family-based designs. The use of these approaches to investigate causal mechanisms in specific scenarios (e.g., maternal smoking during pregnancy and ADHD in offspring) is also covered. This volume is therefore an essential read for geneticists, epidemiologists, and all biomedical scientists and public health professionals dedicated to using genetic information to improve human health. | ||||
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Publication Date | 2022/2022 | |||
Bibliographic Information 254 pages, illustrated (27 color and 23 B&W), index | ||||
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Title Concerning the Origin of Malignant Tumours
Unique URL http://www.cshlpress.com/link/cnorgtmr.htm | ||||
ISBN | 978-087969788-4 | |||
Price | $25.00 | |||
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An English translation of Boveri's famous monograph which was first Written almost a hundred years ago, | ||||
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Publication Date | 2008/2008 | |||
Bibliographic Information 82 pp. | ||||
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The Cells of the Body: A History of Somatic Cell Genetics |
Title Connecting with Companies: A Guide to Consulting Agreements for Biomedical Scientists
Unique URL http://www.cshlpress.com/link/ConnectwComp.htm | ||||
ISBN | 978-1-621821-07-6 | |||
Price | $39 | |||
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An essential guide for academic scientists and physicians who are considering consulting work in biomedicine Before signing a consulting agreement, this must-have reference will help you understand the key issues to consider—from intellectual property, confidentiality, and compensation, to often overlooked issues such as indemnity, different classes of stock, and the relevance of insider trading and securities laws. Read Connecting with Companies and you will:
For more information visit Bioagreements.org Connecting with Companies is an invaluable resource for students, staff, and faculty. To assist you with ordering multiple copies for your institution, we’ve set up the following discount options: | ||||
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Publication Date | 2014/2014 | |||
Bibliographic Information 156 pp., glossary, index Buy 10-19 copies—30% off | ||||
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Title Conscience and Courage: How Visionary CEO Henri Termeer Built a Biotech Giant and Pioneered the Rare Disease Industry
Unique URL http://www.cshlpress.com/link/conscienceandcourage.htm | ||||
ISBN | 978-1-621823-70-4 | |||
Price | $29 | |||
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Henri Termeer was one of the first of a pioneering group of business executives who built a disparate group of fledgling companies into a biotech industry that has driven decades of therapeutic innovation. During a 28-year career at Genzyme, including 26 years as CEO, he created a process of drug development that for the first time was patient-centered. He also helped forge biotech's public policy agenda and inspired a generation of entrepreneurs to take on large and important challenges. An extraordinary number of today's biotech leaders were directly mentored by Termeer. His own leadership was iconoclastic: He broke rules and took risks, setting ambitious goals and finding novel ways to reach them. In doing so he transformed an industry and brought hope to patients with a range of diseases previously deemed too rare to justify the investment needed to support the development of specific therapies. Advanced praise: “Without Henri Termeer, patients with rare diseases would have no hope for new medicines. This authoritative book brings home the highs and the lows —John Maraganore, CEO, Alnylam Pharmaceuticals “Henri Termeer, through his relentless commitment to patients, created a winning global company and unleashed the era of transformative medicines for rare disease. His astonishing business acumen is only surpassed by his humanity-care for individual patients, his colleagues, his family, and his friends. John Hawkins masterfully captures the incredible business story as well as the amazing essence of the man.” —Deborah Dunsire, MD, President & CEO, H. Lundbeck A/S “Henri Termeer led a remarkable life. By pioneering the treatment of rare diseases, he transformed the lives of many forgotten patients and families. John Hawkins' account captures this passion and purpose beautifully.” —Robbie Huffines, Global Chairman, Investment Banking, JP Morgan & Co. “Henri Termeer was a pioneer of the biotechnology industry, combining an astute business mind with a deep passion and empathy for patients and their families. He shaped, almost out of whole cloth, a company that would shine a light on the path to better medicines to an historically underrepresented group of patients and, in so doing, built Genzyme into a formidable enterprise. John Hawkins tells this story with insight, wit, and warmth, painting an indelible portrait of a remarkable man.” —Vicki L. Sato, PhD, Chairman, Denali Therapeutics “Henri Termeer was among the most talented entrepreneurs I have encountered in my career. His drive, determination, and especially his strategic vision profoundly impacted not only Genzyme, but also the evolution of the biotechnology industry and the development of innovative, new drugs for rare disease patients worldwide. Henri was also a true business statesman in both Boston and the Region who contributed to the prosperity Massachusetts has achieved. John Hawkins’ book captures the richness, depth and complexity of Henri’s life story and his many contributions. His deep research and colorful writing make this a great read.” —Professor Michael Porter, University Professor, Harvard Business School “If any leader ever took risks and founded a humanitarian movement, it was Henri Termeer. A thoughtful man driven by what many viewed as an impossible-to-achieve vision, he recruited and encouraged other leaders, many of whom formed new companies, to push on a frontier that he knew was much bigger than he alone could conquer. This is a wonderful, inspirational book which brilliantly describes the high character of an underappreciated, modern-day hero, a man who has improved, and in some cases saved, the lives of millions who will never know his name.” —Professor Carl J. Schramm, Former President of The Ewing Marion Kauffman Foundation and Seven-times Author, including Burn the Business Plan “The prospects for children born with genetic diseases today are vastly different than they were before Henri Termeer defied convention to build Genzyme. John Hawkins has brought Henri vividly to life on the pages of this book. This is sure to be an inspirational read for anyone interested in understanding how Termeer took such a courageous path to transform the outlook for rare disease patients, giving hope to millions.” —James Geraghty, Former Genzyme Executive and Chairman, Orchard Therapeutics | ||||
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Publication Date | 2019/2019 | |||
Bibliographic Information 222 pages, 32-page photo insert, illustrated (63 B&W), index Buy 10-19 copies—25% off Buy the eBook for Kindle or Apple Books | ||||
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Title Control and Regulation of Stem Cells
Unique URL http://www.cshlpress.com/link/conregstem.htm | ||||
ISBN | 978-087969861-4 | |||
Price | $310 | |||
Series Information: | ||||
Based on presentations by world-renowned investigators at the 73rd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in research on the control and regulation of stem cells. The topics covered include nuclear reprogramming, regulation of stem cell self-renewal and differentiation, the stem cell niche, and signaling and gene regulation in stem cells. Studies of embryonic stem cells and adult stem cells are covered, along with research shedding light on the roles of these cells in regeneration and cancer. | ||||
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Publication Date | 2008/2008 | |||
Bibliographic Information 614 pp., illus., indexes | ||||
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Control and Regulation of Stem Cells Stem Cell Biology Stem Cell Biology |
Title Control and Regulation of Stem Cells
Unique URL http://www.cshlpress.com/link/conregstemp.htm | ||||
ISBN | 978-087969862-1 | |||
Price | $126 | |||
Series Information: | ||||
Based on presentations by world-renowned investigators at the 73rd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in research on the control and regulation of stem cells. The topics covered include nuclear reprogramming, regulation of stem cell self-renewal and differentiation, the stem cell niche, and signaling and gene regulation in stem cells. Studies of embryonic stem cells and adult stem cells are covered, along with research shedding light on the roles of these cells in regeneration and cancer. | ||||
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Publication Date | 2008/2008 | |||
Bibliographic Information 614 pp., illus., indexes | ||||
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Related Products |
Control and Regulation of Stem Cells Stem Cell Biology Stem Cell Biology |
Title Correcting the Blueprint of Life: An Historical Account of the Discovery of DNA Repair Mechanisms
Unique URL http://www.cshlpress.com/link/corblu.htm | ||||
ISBN | 978-087969507-1 | |||
Price | $27 | |||
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Publication Date | June 1997/1997 | |||
Bibliographic Information 210 pp., illus., index | ||||
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Title CRISPR-Cas: A Laboratory Manual
Unique URL http://www.cshlpress.com/link/CRISPR-Casp.htm | ||||
ISBN | 978-1-621821-31-1 | |||
Price | $110 | |||
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The development of CRISPR-Cas technology is revolutionizing biology. Based on machinery bacteria use to target foreign nucleic acids, these powerful techniques allow investigators to edit nucleic acids and modulate gene expression more rapidly and accurately than ever before. Featuring contributions from leading figures in the CRISPR-Cas field, this laboratory manual presents a state-of-the-art guide to the technology. It includes step-by-step protocols for applying CRISPR-Cas-based techniques in various systems, including yeast, zebrafish, Drosophila, mice, and cultured cells (e.g., human pluripotent stem cells). The contributors cover web-based tools and approaches for designing guide RNAs that precisely target genes of interest, methods for preparing and delivering CRISPR-Cas reagents into cells, and ways to screen for cells that harbor the desired genetic changes. Strategies for optimizing CRISPR-Cas in each system—especially for minimizing off-target effects—are also provided. Authors also describe other applications of the CRISPR-Cas system, including its use for regulating genome activation and repression, and discuss the development of next-generation CRISPR-Cas tools. The book is thus an essential laboratory resource for all cell, molecular, and developmental biologists, as well as biochemists, geneticists, and all who seek to expand their biotechnology toolkits. | ||||
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Publication Date | 2016/2016 | |||
Bibliographic Information 192 pages, illustrated (20 color, 4 B&W), index | ||||
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Related Products |
Decoding the Language of Genetics DNA Recombination Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics Microbial Evolution Quickstart Molecular Biology: An Introduction for Mathematicians, Physicists, and Computational Scientists RNA: Life's Indispensable Molecule RNA Worlds: From Life's Origins to Diversity in Gene Regulation |
Title CSH Symposia Online Archive
Unique URL not available | ||||
ISBN | 978-087969-860-7 | |||
Price | $3000.00 | |||
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Publication Date | October /2008 | |||
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Title Cystic Fibrosis: A Trilogy of Biochemistry, Physiology, and Therapy
Unique URL http://www.cshlpress.com/link/cysticfibrosis.htm | ||||
ISBN | 978-1-936113-34-7 | |||
Price | $135 | |||
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Cystic fibrosis is caused by mutations in the CFTR gene, which encodes an ion channel protein that regulates anion movement across the epithelial membranes of the lungs, pancreas, and other organs. In cystic fibrosis patients, anion transport is impeded, causing sticky, viscous mucus to build up and clog these vital organs. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides an in-depth examination of cystic fibrosis biology and treatment strategies. Contributors examine the structure and dynamics of CFTR, its normal physiological roles in the airway and digestive epithelia, and how those operations are impaired in patients with cystic fibrosis. The numerous CFTR mutations and how they alter the expression, synthesis, processing, and function of CFTR in cystic fibrosis and other CFTR-related disorders are considered, as are disease-modifying genes that influence disease severity. This volume includes discussions of therapy and treatment strategies for cystic fibrosis, ranging from airway clearance techniques and pancreatic enzyme replacements to the modulation of CFTR and related ion transport pathways. It will be an essential reference for molecular and cellular biologists, physiologists, and clinicians interested in understanding the biological basis of the disease and the search for effective therapies. | ||||
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Publication Date | 2013/2013 | |||
Bibliographic Information 340 pp., illus. (40 4C; 15 B&W), index | ||||
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Title Cytokines: From Basic Mechanisms of Cellular Control to New Therapeutics
Unique URL not available | ||||
ISBN | 978-1-621821-25-0 | |||
Price | $68 | |||
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Cytokines (e.g., interleukins and interferons) are small signaling proteins that are essential for communication between cells. They are important regulators of the immune system, helping to control lymphocyte development and function, orchestrate inflammation, and defeat microbial and viral invaders. But they also play important roles in the nervous system, embryonic development, and diseases such as cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers the spectrum of cytokines that are produced and their roles in normal physiology and disease. The contributors examine the numerous cytokines and their cognate receptors, the downstream signaling mechanisms (e.g., JAK-STAT pathways) that mediate the effects of cytokines on cells, and the regulators that keep them in check (e.g., long noncoding RNAs and the SOCS and IRF protein families). These molecular interactions are discussed in the context of their physiological effects; the roles of cytokines in the development and activities of the immune system are emphasized. The authors also explore how the actions of cytokines may be modulated for treating patients with autoimmune disorders, immunodeficiency, infections, allergies, and cancer. Thus, this volume is an indispensable reference not only for cell biologists and immunologists but for all who are interested in targeting cytokine signaling for therapeutic purposes. | ||||
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Publication Date | 2018/2018 | |||
Bibliographic Information 470 pages, illustrated (57 color and 4 B&W), index | ||||
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Title The Cytoskeleton
Unique URL http://www.cshlpress.com/link/cytoskeleton.htm | ||||
ISBN | 978-1-621820-16-1 | |||
Price | $135 | |||
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The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. It comprises three major filament systems-actin, microtubules, and intermediate filaments-along with a host of adaptors, regulators, molecular motors, and additional structural proteins. This textbook presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture. It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. The book is thus essential reading for students learning about intracellular structure. It also represents a vital reference for all cell and developmental biologists working in this field. | ||||
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Publication Date | 2017/2017 | |||
Bibliographic Information 391 pages, illustrated (100 color and 22 B&W), index | ||||
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Title Davenport's Dream: 21st Century Reflections on Heredity & Eugenics
Unique URL not available | ||||
ISBN | 978-162182232-5 | |||
Price | $29 | |||
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In 1911, the influential geneticist Charles Davenport published Heredity in Relation to Eugenics, advancing his ideas of how genetics would improve society in the 20th century. It became a college textbook and a foundation for the widespread eugenics movement in the United States. Nearly 100 years later, many of the issues raised by Davenport are again being debated, in different guises. In this new volume, prominent academics discuss themes from Davenport's book—human genetic variation, mental illness, nature vs. nurture, human evolution—in a contemporary context. Davenport's original book is reprinted along with the essays. This book will be useful to historians of science as well as those interested in the social implications of human genetics research—past, present, and future. | ||||
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Publication Date | 2008/2008 | |||
Bibliographic Information 490 pp., illus. | ||||
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Title The Dawn of Human Genetics
Unique URL http://www.cshlpress.com/link/dawnhumgen.htm | |||||
ISBN | 978-1-936113-70-5 | ||||
Price | $69 | ||||
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In Russia, the initial euphoria of the Bolshevik leaders for a new socialist society ... combined with a commitment to a truly universal health care system, gave a huge boost to the emergence of both the eugenic and medical aspects of human genetics. The obstacles that proved so formidable to the successful launch of the field in the West—the lack of available data on the genealogy of diseases in families, the difficulty in getting a statistically significant number of identical twins to study, and the skepticism of the medical establishment—were all swept aside in the Soviet Union. In the 1920s ... the groundwork was laid for a uniquely Russian approach to medical genetics and (the foundation of) the world’s leading center for the study of the genetic basis of many diseases and human genetics in general. The immense success of the movement, which is little known even to Russians, is brought to life in V.V. Babkov’s The Dawn of Human Genetics, as is its dramatic and violent end, which resulted in the “liquidation” of many of the country’s finest biologists, as well as a major setback to the development of world science. Like many other promising ideas and projects that were born in the Soviet Union, this one was abruptly truncated and then virtually eradicated. | |||||
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Publication Date | 2013/2013 | ||||
Bibliographic Information 775 pp., illus. (91 B&W ), index | |||||
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Title Decoding the Language of Genetics
Unique URL http://www.cshlpress.com/link/languagegenetics.htm | ||||
ISBN | 978-1-621820-92-5 | |||
Price | $79 | |||
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In this book, the distinguished geneticist David Botstein offers help and advice to scientists and physicians daunted by the arcane technical terms that flourish in his discipline. The science of gene function has a vocabulary of specialized, sometimes confusing terms to explain how traits and diseases are inherited, how genes are organized and regulated in the genome, and how the genetic code is read and translated by cells. These terms are often a barrier to full understanding of the underlying concepts. Yet, as more and more individuals learn about their genomes, the information these sequences contain cannot be understood or explained without reference to the basic ideas of genetics. Botstein draws on his long experience as a teacher and pioneering scientist to explain and illuminate what many genetic terms mean and how they entered common usage. | ||||
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Publication Date | 2015/2015 | |||
Bibliographic Information 240 pages, illustrated (30 color, 10 B&W), index | ||||
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Title The Development of Drosophila melanogaster
Unique URL http://www.cshlpress.com/link/devdrosp.htm | ||||
ISBN | 978-087969899-7 | |||
Price | $256.00 | |||
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The fruit fly Drosophila melanogaster offers the most powerful means of studying embryonic development in eukaryotes. New information from many different organ systems has accumulated rapidly in the past decade. This monograph, written by the most distinguished workers in the field, is the most authoritative and comprehensive synthesis of Drosophila developmental biology available and emphasizes the insights gained by molecular and genetic analysis. In two volumes, it is a lavishly illustrated, elegantly designed reference work illustrating principles of genetic regulation of embryogenesis that may apply to other eukaryotes. | ||||
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Publication Date | 1993/1993 | |||
Bibliographic Information 1,564 pp. (2-volume set), illus., indexes | ||||
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Title The Digital Cell: Cell Biology as a Data Science
Unique URL http://www.cshlpress.com/link/digitalcell.htm | ||||
ISBN | 978-1-621822-78-3 | |||
Price | $67 | |||
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Cell and molecular biology are becoming increasingly data driven. Technological advances and increased computing power mean that researchers now increasingly quantify experimental results, rather than simply report qualitative, representative observations. The Digital Cell provides a comprehensive guide for scientists seeking to make this transition. It describes how data should be generated and processed, discussing research workflows, pipelines, and storage solutions. A key focus of the book is imaging—image types and formats are explained, as is software for image processing and analysis, along with techniques such as segmentation analysis and automated particle tracking. The book examines the wide variety of statistical approaches that can be used for data analysis, emphasizing concepts such as significance and reproducibility. It also includes an introduction to coding, including examples of how to write and use R scripts to analyze results. In addition, there is useful advice on how to plot and present data to convey results most effectively. The Digital Cell is thus an essential resource for all cell and molecular biologists—from students embarking on research for the first time to experienced scientists who need to acquire, process, and present their data accurately and efficiently. | ||||
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Publication Date | 2020/2020 | |||
Bibliographic Information 137 pages, illustrated (2 color and 26 B&W), index | ||||
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Topics |
Title Discovering the Double Helix
Unique URL http://www.cshlpress.com/link/dblhelix.htm | ||||
ISBN | 978-087969622-1 | |||
Price | $21 | |||
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Publication Date | October 2001/2001 | |||
Bibliographic Information 60-minute video | ||||
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Related Products |
Discovering the Double Helix A Passion for DNA: Genes, Genomes, and Society A Passion for DNA: Genes, Genomes, and Society Winding Your Way Through DNA Winding Your Way Through DNA Houses for Science: A Pictorial History of Cold Spring Harbor Laboratory Stories from the Scientists Stories from the Scientists |
Title DNA Interactive DVD
Unique URL http://www.cshlpress.com/link/dnadvd.htm | ||||
ISBN | 978-097105881-1 | |||
Price | $33.00 | |||
Series Information: | ||||
“DNA has come a long way.” James D. Watson, Nobel Laureate DNA Interactive (DNAi) is a multimedia resource for high school and introductory college biology that shows how we came to understand the language of DNA, how we bend it to our own service, and what it can tell us about who we are. The DNAi products—an award winning website (http://www.dnai.org) and the DVD—are the result of a two–year collaboration between scientists, educators, and film–makers on three continents. It includes more than 200 video clips and animations; video interviews with 11 Nobel Laureates and more than 50 other scientists, clinicians, and patients; and spectacular 3–D animations that illustrate intracellular processes and explore aspects of DNA science. | ||||
Producer
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Publication Date | /2003 | |||
Bibliographic Information DVD disc (NTSC version—unencoded), 4 hours (approx.) of viewing | ||||
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Title DNA Recombination
Unique URL http://www.cshlpress.com/link/dnarecomb.htm | ||||
ISBN | 978-1-621820-09-3 | |||
Price | $135 | |||
Series Information: | ||||
Homologous recombination involves the precise exchange of similar or identical nucleic acid sequences between two DNA molecules. This process directs the repair of many DNA lesions in somatic cells and generates genetic variation in sperm and egg cells during meiosis. It is a nearly universal biological process that is conserved from phage to humans. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of recombinational DNA repair, meiotic recombination, and the regulation of these processes. The contributors examine the dozens of proteins that are involved in recombinational repair and the various pathways in which they are employed (e.g., gene conversion or break-induced replication). They also discuss how these proteins and pathways are strictly regulated to avoid genomic instability, which can lead to diseases such as cancer, and how they are coordinated with other nuclear processes (e.g., transcription and DNA replication). Meiotic recombination, the characteristics that distinguish it from recombinational repair, and effects of its dysregulation (e.g., aneuploidy) are also covered in depth. This volume is an indispensable reference for biochemists, molecular biologists, and cell biologists who want to understand how DNA recombination maintains genomic integrity in individual organisms and across generations. | ||||
Editor
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Publication Date | 2016/2016 | |||
Bibliographic Information 549 pages, illustrated (87 color, 9 B&W), index | ||||
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Title DNA Replication
Unique URL http://www.cshlpress.com/link/dnareplication.htm | ||||
ISBN | 978-1-936113-48-4 | |||
Price | $135 | |||
Series Information: | ||||
DNA replication is essential for the propagation of life on Earth. Cells in living organisms must be able to synthesize a complete copy of their DNA with extraordinary precision, so that they can pass this genetic material on to their descendants. DNA replication involves the coordinated interplay and regulation of many complex protein assemblies during the various stages of cell division. When these processes go awry, cancer and other diseases can ensue. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of DNA replication and its control across all domains of life. The contributors examine the molecular machinery involved in the assembly of replication origin complexes, the establishment of replication forks, unzipping of the double helix, priming of DNA synthesis, and elongation of daughter strands. Chromatin organization and dynamics, lagging-strand maturation, telomere replication, and mechanisms to handle errors and damage in DNA are also discussed. Including examination of the complex interactions between the core replication machinery and the regulatory circuits that drive cell cycle progression, this volume is an indispensable reference for not only biochemists and molecular biologists, but also cell biologists and all who want to understand this fundamental process of life. | ||||
Editor
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Publication Date | 2013/2013 | |||
Bibliographic Information 576 pp., illus. (88 4C, 33 B&W), appendices, index | ||||
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Title DNA Replication and Human Disease
Unique URL http://www.cshlpress.com/link/dnarep2.htm | ||||
ISBN | 978-087969766-2 | |||
Price | $139 | |||
Series Information: | ||||
At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA! And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? This book addresses these questions by presenting a thorough analysis of the molecular events that govern DNA replication in eukaryotic cells. The association between genome replication and cell proliferation, disease pathogenesis, and the development of targeted therapeutics is also addressed. At least 160 proteins are involved in replicating the human genome, and at least 40 diseases are caused by aberrant DNA replication, 35 by mutations in genes required for DNA replication or repair, 7 by mutations generated during mitochondrial DNA replication, and more than 40 by DNA viruses. Consequently, a growing number of therapeutic drugs are targeted to DNA replication proteins. This authoritative volume provides a rich source of information for researchers, physicians, and teachers, and will stimulate thinking about the relevance of DNA replication to human disease. | ||||
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Publication Date | 2006/2006 | |||
Bibliographic Information 814 pp., illus., appendices, index | ||||
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Related Products |
DNA Replication in Eukaryotic Cells |
Title DNA Science: A First Course, Second Edition
Unique URL http://www.cshlpress.com/link/dnasci2p.htm | ||||
ISBN | 978-1-936113-17-0 | |||
Price | $46.00 | |||
Series Information: | ||||
This is the second edition of a highly successful textbook (over 50,000 copies sold) in which a highly illustrated, narrative text is combined with easy–to–use thoroughly reliable laboratory protocols. It contains a fully up–to–date collection of 12 rigorously tested and reliable lab experiments in molecular biology, developed at the internationally renowned Dolan DNA Learning Center of Cold Spring Harbor Laboratory, which culminate in the construction and cloning of a recombinant DNA molecule. Proven through more than 10 years of teaching at research and nonresearch colleges and universities, junior colleges, community colleges, and advanced biology programs in high school, this book has been successfully integrated into introductory biology, general biology, genetics, microbiology, cell biology, molecular genetics, and molecular biology courses. The first eight chapters have been completely revised, extensively rewritten, and updated. The new coverage extends to the completion of the draft sequence of the human genome and the enormous impact these and other sequence data are having on medicine, research, and our view of human evolution. All sections on the concepts and techniques of molecular biology have been updated to reflect the current state of laboratory research. The laboratory experiments cover basic techniques of gene isolation and analysis, honed by over 10 years of classroom use to be thoroughly reliable, even in the hands of teachers and students with no prior experience. Extensive prelab notes at the beginning of each experiment explain how to schedule and prepare, while flow charts and icons make the protocols easy to follow. As in the first edition of this book, the laboratory course is completely supported by quality–assured products from the Carolina Biological Supply Company, from bulk reagents, to useable reagent systems, to single–use kits, thus satisfying a broad range of teaching applications. | ||||
Author
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Publication Date | 2003/2003 | |||
Bibliographic Information 575 pp., illus., appendices, index | ||||
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Related Products |
Genome Science: A Practical and Conceptual Introduction to Molecular Genetic Analysis in Eukaryotes DNA Science: A First Course, Second Edition |
Title Double Talking Helix Blues
Unique URL http://www.cshlpress.com/link/dbltalk.htm | |||||
ISBN | 978-087969431-9 | ||||
Price | $16 | ||||
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Publication Date | January 1994/1994 | ||||
Bibliographic Information 32 fully illustrated 4-color pages | |||||
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Title Drosophila Neurobiology: A Laboratory Manual
Unique URL http://www.cshlpress.com/link/drosneurop.htm | ||||
ISBN | 978-0-879699-05-5 | |||
Price | $154.00 | |||
Series Information: | ||||
Cold Spring Harbor Laboratory’s long-running Neurobiology of Drosophila course has trained a generation of neuroscientists, many of whom have become leaders in the field. Drosophila Neurobiology: A Laboratory Manual offers the detailed protocols and background material developed by the course instructors to all researchers interested in using Drosophila as an experimental model for investigating the nervous system. The manual covers three approaches to the field: Studying Neural Development in Drosophila melanogaster, Recording and Imaging in the Drosophila Nervous System, and Studying Behavior in Drosophila. Techniques described include molecular, genetic, electrophysiological, imaging, behavioral and developmental methods. Written by leading experts from the community, Drosophila Neurobiology: A Laboratory Manual is an essential guide for researchers at all levels, from the beginning graduate student through the established primary investigator. | ||||
Editor
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Publication Date | 2010/2010 | |||
Bibliographic Information 534 pp., illus. (70 color, 43 b/w), appendix, index Trim size: 8-1/2" x 10-7/8" | ||||
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Related Products |
Drosophila Neurobiology: A Laboratory Manual Invertebrate Neurobiology An Introduction to Nervous Systems An Introduction to Nervous Systems |
Title Drosophila Protocols
Unique URL http://www.cshlpress.com/link/drosprotp.htm | ||||
ISBN | 978-087969827-0 | |||
Price | $81.00 | |||
Series Information: | ||||
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Publication Date | March 2000/2000 | |||
Bibliographic Information 728 pp., illus., appendices, index | ||||
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Title The Dynamic Genome: Barbara McClintock's Ideas in the Century of Genetics
Unique URL http://www.cshlpress.com/link/dyngenp.htm | ||||
ISBN | 978-087969396-1 | |||
Price | $29 | |||
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Publication Date | JANUARY 1992/1992 | |||
Bibliographic Information 422 pp., illus, indexes This book has been produced using print on demand technology. | ||||
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Title The Early Days of Yeast Genetics
Unique URL http://www.cshlpress.com/link/earlydayp.htm | |||||
ISBN | 978-087969874-4 | ||||
Price | $61.00 | ||||
Series Information: | |||||
Yeast genetics began with Winge's 1935 studies of S. cerevisiae in Copenhagen, and afterwards was pursued by Lindegren in the U.S. and Ephrussi in France. Genetic studies in S. pombe were pioneered by Leupold in the 1940s in Switzerland. Within four decades, not without controversies, both yeast species were recognized as essential models in eukaryotic molecular cell biology. In this remarkable volume, Hall and Linder have assembled the reminiscences of many early investigators whose pioneering studies in the years before 1975 brought yeast biology to its current maturity. These illustrated essays about the science, the events and the personalities involved capture a fascinating era, in the informal style made famous by Phage and the Origins of Molecular Biology. This is a book that all scientists interested in the development of modern genetics and molecular biology should have on their shelves. | |||||
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Publication Date | JANUARY 1993/1993 | ||||
Bibliographic Information 477 pp., illus., indexes | |||||
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The Early Days of Yeast Genetics Phage and the Origins of Molecular Biology, The Centennial Edition |
Title Early Development of Xenopus laevis: A Laboratory Manual
Unique URL http://www.cshlpress.com/link/earlyxenp.htm | ||||
ISBN | 978-087969942-0 | |||
Price | $40.00 | |||
Series Information: | ||||
This volume is essential reading for all investigators interested in the developmental and cell biology of Xenopus and vertebrates generally. Many of the techniques described here are illustrated in an accompanying set of videotapes which are cross-referenced to the appropriate section of the manual. | ||||
Author
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Publication Date | 2000/2000 | |||
Bibliographic Information 338 pp., illus., color plate, appendices, index | ||||
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Related Products |
Early Development of Xenopus laevis: A Laboratory Manual Early Development of Xenopus laevis: A Laboratory Manual Manipulating the Early Embryo of Xenopus laevis: A Video Guide Manipulating the Early Embryo of Xenopus laevis: A Video Guide |
Title The Eighth Day of Creation: The Makers of the Revolution in Biology (Commemorative Edition) Unique URL http://www.cshlpress.com/link/eighthp.htm | ||||
ISBN | 978-087969478-4 | |||
Price | $56.00 | |||
Series Information: | ||||
In this classic book, the distinguished science writer Horace Freeland Judson tells the story of the birth and early development of molecular biology in the US, the UK, and France. The fascinating story of the golden period from the revelation of the double helix of DNA to the cracking of the genetic code and first glimpses of gene regulation is told largely in the words of the main players, all of whom Judson interviewed extensively. The result is a book widely regarded as the best history of recent biological science yet published. This commemorative edition, honoring the memory of the author who died in 2011, contains essays by his daughter Olivia Judson, Matthew Meselson, and Mark Ptashne and an obituary by Jason Pontin. It contains all the content added to previous editions, including essays on some of the principal historical figures involved, such as Rosalind Franklin, and a sketch of the further development of molecular biology in the era of recombinant DNA. | ||||
Author
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Publication Date | 1996/1996 | |||
Bibliographic Information 720 pp., illus., index, appendix, notes | ||||
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Topics |
Title Emerging Model Organisms: A Laboratory Manual, Volume 1
Unique URL http://www.cshlpress.com/link/emo.htm | ||||
ISBN | 978-087969826-3 | |||
Price | $158 | |||
Series Information: | ||||
Until recently, a small number of model organisms has been the focus of most research in molecular, cellular, and developmental biology. But in the last few years, due in part to increased interest in questions of evolution, technical advances in selectively altering gene expression patterns, and the reduced costs of genome sequencing, the range of organisms used for research is greatly expanding. Emerging Model Organisms, Volume 1, introduces the reader to this new generation of model organisms, providing a diverse catalog of potential species useful for extending research in new directions. In this volume leading experts provide chapters on 23 emerging model systems, ranging from bat and butterfly to cave fish and choanoflagellates; cricket and finch to quail, snail, and tomato. Subsequent releases of the Emerging Model Organisms series, already in preparation, will focus on additional species. Material is also available in CSH Protocols: www.cshprotocols.org/emo | ||||
Publication Date | 2009/2009 | |||
Bibliographic Information 592 pp., illus., appendix, index | ||||
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Related Products |
Emerging Model Organisms: A Laboratory Manual, Volume 1 |
Title Emerging Model Organisms: A Laboratory Manual, Volume 1
Unique URL http://www.cshlpress.com/link/emop.htm | ||||
ISBN | 978-087969872-0 | |||
Price | $89 | |||
Series Information: | ||||
Until recently, a small number of model organisms has been the focus of most research in molecular, cellular, and developmental biology. But in the last few years, due in part to increased interest in questions of evolution, technical advances in selectively altering gene expression patterns, and the reduced costs of genome sequencing, the range of organisms used for research is greatly expanding. Emerging Model Organisms, Volume 1, introduces the reader to this new generation of model organisms, providing a diverse catalog of potential species useful for extending research in new directions. In this volume leading experts provide chapters on 23 emerging model systems, ranging from bat and butterfly to cave fish and choanoflagellates; cricket and finch to quail, snail, and tomato. Subsequent releases of the Emerging Model Organisms series, already in preparation, will focus on additional species. Material is also available in CSH Protocols: www.cshprotocols.org/emo | ||||
Publication Date | 2009/2009 | |||
Bibliographic Information 592 pp., illus., appendix, index | ||||
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Related Products |
Emerging Model Organisms: A Laboratory Manual, Volume 1 |
Title Endocytosis
Unique URL http://www.cshlpress.com/link/endocytosis.htm | ||||
ISBN | 978-1-621820-24-6 | |||
Price | $135 | |||
Series Information: | ||||
During endocytosis, extracellular molecules and plasma membrane components are selectively internalized by cells. This fundamental process of “cellular ingestion” is required for diverse activities such as nutrient uptake, cell adhesion and migration, signal transduction, cytokinesis, neurotransmission, and antigen presentation. Pathogens (e.g., HIV) exploit endocytic pathways to gain entry into cells, and defects in the endocytic machinery can lead to diseases such as cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all of the major pathways of endocytosis and postendocytic trafficking and how they regulate cellular and organismal physiology. Contributors describe how cargo enters the cell via clathrin-mediated and clathrin-independent pathways, including caveolar endocytosis, micropinocytosis, cholesterol-sensitive endocytosis, phagocytosis, and the CLIC/GEEC pathway. They review the numerous machineries (e.g., Rab GTPases, tethering factors, and retromer) that transport cargo through endosomes and deliver it to lysosomes or recycle it back to the cell surface, and the signals and mechanisms governing these sorting decisions. Topics such as lysosomal dynamics, the biophysical challenges of bending membranes, and the evolution of endocytic systems are also covered. This volume also includes substantial discussion of the roles of endocytic trafficking in organismal development, physiology, and disease. It is thus an indispensable reference for cell biologists, but also for neuroscientists, immunologists, developmental biologists, microbiologists, and others concerned with the physiological and therapeutic implications of this key cellular process. | ||||
Editor
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Publication Date | 2014/2014 | |||
Bibliographic Information 590 pp., illus., index | ||||
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Title The Endoplasmic Reticulum
Unique URL http://www.cshlpress.com/link/endoplasret.htm | ||||
ISBN | 978-1-936113-82-8 | |||
Price | $135 | |||
Series Information: | ||||
The endoplasmic reticulum (ER) is an extensive network of membranes that folds, modifies, and transports proteins in eukaryotic cells. It also manufactures lipids and interacts extensively with other organelles, playing essential roles in cell growth and homeostasis. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of ER morphology and function, as well as its interactions with the nucleus, Golgi, and mitochondria. Contributors examine how proteins translocate across the ER membrane, the processes that occur inside the ER lumen (e.g., folding, glycosylation, and disulfide bond formation), and how the proteins are packaged into vesicles and transported to the Golgi. They also review quality-control mechanisms that are employed by the ER to detect and eliminate misfolded or unassembled proteins. Lipid synthesis and transport are also discussed. This volume covers not only the biochemistry and cell biology of the ER, but also ER stress, metabolism, and the role of the ER in viral replication. Thus, it is an essential reference for cell biologists, physiologists, and pathologists interested in understanding the numerous functions of the ER. | ||||
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Publication Date | 2013/2013 | |||
Bibliographic Information 336 pp., illus (61 4C, 9 B&W), index | ||||
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Title The Endoplasmic Reticulum, Second Edition
Unique URL not available | ||||
ISBN | 978-1-621824-37-4 | |||
Price | $135 | |||
Series Information: | ||||
The endoplasmic reticulum (ER) is a network of membranes that folds, modifies, and transports proteins in eukaryotic cells. It also manufactures lipids and interacts extensively with other organelles, playing essential roles in cell growth and homeostasis. Written and edited by experts in the field, this new collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on advances in our understanding of the structure and multiple functions of the ER. The contributors examine how proteins enter the ER, the biogenesis of membrane proteins, and the role of the ER in protein sorting and quality control. In addition, they discuss how lipids are synthesized and transported to and from the ER. The volume reviews the architecture of the ER and the ways in which it interacts with other organelles. The consequences for metabolic health and neurodegeneration are also considered. It is thus an essential reference for cell biologists, as well as physiologists and pathologists interested in understanding the role of the ER in disease. | ||||
Editor
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Publication Date | 2023/2023 | |||
Bibliographic Information 368 pages, illustrated (89 color and 1 B&W), index | ||||
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Title Engineering Plants for Agriculture
Unique URL not available | ||||
ISBN | 978-1-621823-12-4 | |||
Price | $135 | |||
Series Information: | ||||
Agriculture plays a vital role supporting human life on Earth but faces significant challenges to feed the growing population. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the molecular bases of plant traits and addresses how this knowledge can be used to develop crops that are resilient to a changing environment. The contributors review recent advances in our understanding of plant plasticity, circadian rhythms, stomatal development, inflorescence architecture, symbiotic phosphate acquisition, and specialized plant metabolism and discuss how this knowledge might be used to boost yields, improve tolerance to pathogens and environmental stress, and enhance nutritional content. The book also discusses the development and socioeconomic impact of deployment of genetically improved submergence-tolerant rice. The generation of blight-resistant American chestnut trees—the first bioengineered plant developed with the goal of ecological restoration—is also described. This volume is therefore an essential read for all plant biologists, geneticists, and engineers interested in addressing agricultural and environmental challenges. | ||||
Editor
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Publication Date | 2019/2019 | |||
Bibliographic Information 232 pages, illustrated (37 color and 7 B&W), index | ||||
Set Info | ||||
Topics |
Title Enjoy Your Cells
Unique URL http://www.cshlpress.com/link/enjycell.htm | ||||
ISBN | 978-087969584-2 | |||
Price | $9.95 | |||
Series Information: | ||||
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Author
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Publication Date | November 2001/2002 | |||
Bibliographic Information 32 fully illustrated 4-color pages | ||||
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Enjoy Your Cells |
Title Enjoy Your Cells Coloring Book
Unique URL http://www.cshlpress.com/link/enjoycolor.htm | ||||
ISBN | 978-1-621822-11-0 | |||
Price | $12.95 | |||
Series Information: | ||||
Color and learn! Beneath your skin there is an amazing hidden world of living cells. Millions and millions of cells work together, to make everything that is you. But did you know that you started life as just one tiny cell? And did you know that everything that lives on Planet Earth is also made of these amazing cells? From the acclaimed creative partnership of scientist/author Fran Balkwill and illustrator Mic Rolph, the Enjoy Your Cells Color and Learn Series is an entertaining, one-of-a-kind learning experience that you help to create. Each coloring book incorporates all of the original text and artwork from the best-selling Enjoy Your Cells series, now in a delightfully enlarged format suitable for coloring book fans of all ages. The pages are brimming with dozens of drawings of cells, proteins, and DNA, accompanied by easy-to-understand but scientifically accurate commentary. Proceeds from the books help to support research and education at the world-renowned Cold Spring Harbor Laboratory. With exuberant graphics ranging from simple to intricate, these books are sure to bring hours of educational enjoyment to budding and experienced scientists alike! | ||||
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Publication Date | 2016/2016 | |||
Bibliographic Information 32 fully illustrated ready-to-color pages | ||||
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Related Products |
Germ Zappers Coloring Book Have a Nice DNA Coloring Book Gene Machines Coloring Book Enjoy Your Cells Series Coloring Books, 4-book Gift Set |
Title Enjoy Your Cells Series Coloring Books, 4-book Gift Set
Unique URL http://www.cshlpress.com/link/enjoycolorset.htm | ||||
ISBN | 978-1-621821-94-6 | |||
Price | $44 | |||
Series Information: | ||||
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Author
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Publication Date | 2016/2016 | |||
Bibliographic Information 32 fully illustrated ready-to-color pages in each book Enjoy Your Cells Coloring Book ISBN 978-1-621822-11-0 Germ Zappers Coloring Book ISBN 978-1-621821-91-5 Have a Nice DNA Coloring Book ISBN 978-1-621821-92-2 Gene Machines Coloring Book ISBN 978-1-621821-93-9 | ||||
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Related Products |
Enjoy Your Cells Coloring Book Germ Zappers Coloring Book Have a Nice DNA Coloring Book Gene Machines Coloring Book |
Title Enjoy Your Cells-Balkwill/Rolph 4-book set
Unique URL http://www.cshlpress.com/link/enjoy4p.htm | ||||
ISBN | 9781621820024 | |||
Price | $35 | |||
Series Information: | ||||
A collection of all four titles in the Enjoy Your Cells series for one low price. Enjoy Your Cells is a new series of children's books from the acclaimed creative partnership of scientist/author Fran Balkwill and illustrator Mic Rolph. Once again, they use their unique brand of simple but scientifically accurate commentary and exuberantly colorful graphics to take young readers on an entertaining exploration of the amazing, hidden world of cells, proteins, and DNA. It's over ten years since Fran and Mic invented a new way of getting science across to children. Think what extraordinary advances have been made in biology in that time—and how often those discoveries made headlines. Stem cells, cloning, embryo transfer, emerging infections, vaccine development…here in these books are the basic facts behind the public debates. With these books, children will learn to enjoy their cells and current affairs at the same time. And they're getting information that has been written and reviewed by working scientists, so it's completely correct and up-to-date. Readers aged 7 and up will appreciate the stories' lively language and with help, even younger children will enjoy and learn from the jokes and illustrations—no expert required! This series is a must for all elementary school students and those who care about educating them to be well-informed in a world of increasingly complex health-related and environmental issues. Fran Balkwill is Professor of Cancer Biology at St. Bartholomew's Hospital and the London Queen Mary School of Medicine. Mic Rolph is a graphic designer with much television and publishing experience. Together, they have created many books for children, and have won several awards, including the prestigious COPUS Junior Science Book Prize.
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Publication Date | 2002/2002 | |||
Bibliographic Information 32 fully illustrated 4-color pages in each book. Enjoy Your Cells ISBN 978-087969584-2 Germ Zappers ISBN 978-087969598-9 Have a Nice DNA ISBN 978-087969610-8 Gene Machines ISBN 978-087969611-5 | ||||
Set Info | ||||
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Title Enteric Hepatitis Viruses
Unique URL http://www.cshlpress.com/link/enthepvirus.htm | ||||
ISBN | 978-1-621821-62-5 | |||
Price | $135 | |||
Series Information: | ||||
Viruses that are transmitted via the fecal–oral route and may cause liver damage are known as enteric hepatitis viruses. These viruses, which include the hepatitis A and E viruses (HAV and HEV, respectively), infect millions of individuals worldwide and pose significant threats to public health. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines recent progress in our understanding of the biology and pathogenic mechanisms of HAV and HEV, as well as prospects for improving their control. Contributors explore the molecular characteristics and life cycles of HAV and HEV, their interactions with the liver and immune system, the clinical manifestations of the infections they cause, and their transmission via contaminated food and water. Additional topics include the geographic distributions of the various HAV and HEV genotypes, factors that influence their changing epidemiology, and the development of effective vaccines and vaccination strategies. The authors also discuss advances in cell-culture systems and animal models, as well as how studies of HAV and HEV may provide insight into other viruses and infectious diseases of the liver. This volume is therefore an essential reference for all virologists, immunologists, pathologists, clinicians, and public health professionals. | ||||
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Publication Date | 2018/2018 | |||
Bibliographic Information 400 pages, illustrated (69 color and 24 B&W), index | ||||
Set Info | ||||
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Title Epigenetics, Second Edition
Unique URL http://www.cshlpress.com/link/epigen2.htm | ||||
ISBN | 978-1-936113-59-0 | |||
Price | $165 | |||
Series Information: | ||||
In many biological processes the regulation of gene expression involves epigenetic mechanisms. In this new edition of Epigenetics, 36 chapters written by experts in the field introduce and explain epigenetic effects from many perspectives. These include the varied molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of model organisms in which epigenetic effects have been most studied. The original chapters have all been rewritten and brand new chapters cover topics such as the structure, function, and dynamics of histone-modifying enzymes and histone-interacting proteins. Other chapters address chromatin remodeling, DNA methylation, siRNAs, and gene silencing; X-chromosome inactivation, dosage compensation, and imprinting; and epigenetics in microbes, plants, insects, and mammals. How epigenetic mechanisms act in cell division and cell type specification, and how errors in these pathways contribute to cancer and other human diseases are also considered, along with the importance of epigenetics for induced pluripotency and reprogramming. In addition, new chapters describe the involvement of epigenetic processes in epigenetic inheritance, neuronal development, metabolism and signaling, responses to the environment, and long-range chromatin interactions. A series of short essays highlight important recent discoveries. All the chapters provide conceptual illustrations that help readers understand epigenetic control. The book is thus a benchmark text for advanced undergraduate and graduate courses on gene regulation, as well as an essential resource for scientists interested in this rapidly moving field. | ||||
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Publication Date | 2015/2015 | |||
Bibliographic Information 984 pages, illustrated (408 color, 9 B&W), index | ||||
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Title Epilepsy: The Biology of a Spectrum Disorder
Unique URL http://www.cshlpress.com/link/epilepsy.htm | ||||
ISBN | 978-1-621820-94-9 | |||
Price | $135 | |||
Series Information: | ||||
Epilepsy is due to abnormal signaling of neurons in the brain that can cause seizures. It is a common condition, affecting at least 3% of individuals at some point during their life. The seizures are difficult to predict and, in a significant fraction of patients, refractory to current medical interventions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of epilepsy, its causes, pathophysiology, clinical characteristics, comorbidities, and treatment. Contributors discuss the genetic, developmental, and environmental triggers of recurrent seizures; molecular changes (e.g., epigenetic modifications) that are associated with epileptogenesis; and the aberrant ion channels and neuronal networks involved. Clinical aspects of the disease (diagnosis, classification, and treatments) are reviewed, as are common comorbidities (e.g., depression and cognitive disorders). Recent advances in drug development and surgical techniques aimed at reducing the morbidity and mortality of patients with epilepsy are also described. The authors highlight current challenges in the field of epilepsy, with the goal of assisting others in formulating relevant research questions. This volume is therefore a vital reference not only for scientists and clinicians currently working in the field, but for all neuroscientists seeking to explore new research directions. | ||||
Editor
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Publication Date | 2016/2016 | |||
Bibliographic Information 459 pages, illustrated (43 color, 17 B&W), index | ||||
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Related Products |
Epilepsy: The Biology of a Spectrum Disorder |
Title Epilepsy: The Biology of a Spectrum Disorder
Unique URL http://www.cshlpress.com/link/epilepsyp.htm | ||||
ISBN | 978-1-621821-50-2 | |||
Price | $79 | |||
Series Information: | ||||
Epilepsy is due to abnormal signaling of neurons in the brain that can cause seizures. It is a common condition, affecting at least 3% of individuals at some point during their life. The seizures are difficult to predict and, in a significant fraction of patients, refractory to current medical interventions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of epilepsy, its causes, pathophysiology, clinical characteristics, comorbidities, and treatment. Contributors discuss the genetic, developmental, and environmental triggers of recurrent seizures; molecular changes (e.g., epigenetic modifications) that are associated with epileptogenesis; and the aberrant ion channels and neuronal networks involved. Clinical aspects of the disease (diagnosis, classification, and treatments) are reviewed, as are common comorbidities (e.g., depression and cognitive disorders). Recent advances in drug development and surgical techniques aimed at reducing the morbidity and mortality of patients with epilepsy are also described. The authors highlight current challenges in the field of epilepsy, with the goal of assisting others in formulating relevant research questions. This volume is therefore a vital reference not only for scientists and clinicians currently working in the field, but for all neuroscientists seeking to explore new research directions. | ||||
Editor
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Publication Date | 2016/2016 | |||
Bibliographic Information 459 pages, illustrated (43 color, 17 B&W), index | ||||
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Related Products |
Epilepsy: The Biology of a Spectrum Disorder |
Title Essentials of Glycobiology, Fourth Edition
Unique URL not available | ||||
ISBN | 978-1-621824-21-3 | |||
Price | $165 | |||
Series Information: | ||||
Saccharides are widely distributed in all living life-forms, and glycobiology is the study of their structure, biosynthesis, biology, and evolution. It is a rapidly growing field, relevant to many areas of basic research, biomedicine, and biotechnology. The field includes the chemistry of carbohydrates, the enzymology of glycan formation and degradation, the recognition of glycans by specific proteins, the roles of glycans in complex biological systems, and their analysis and manipulation. Essentials of Glycobiology is the field's most authoritative textbook, offering an overview suitable for advanced undergraduates and graduate students in molecular and cellular biology and biomedicine. In an entirely revised and updated fourth edition, the book retains a broad focus and applicability to fields ranging from biology and medicine to chemistry and materials science, with excellent artwork and chapters written by an international selection of leading investigators. | ||||
Editor
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Publication Date | 2022/2022 | |||
Bibliographic Information 859 pages, illustrated (225 color, 58 B&W), index | ||||
Set Info | ||||
Topics |
Title Evolution
Unique URL http://www.cshlpress.com/link/evolutn.htm | ||||
ISBN | 978-087969684-9 | |||
Price | $57.00 | |||
Series Information: | ||||
Evolution is a book on evolutionary biology that integrates molecular biology, genomics, and human genetics with traditional studies of evolutionary processes.
Additional chapters, found on the Web only, deal with techniques and models used in studying evolutionary biology, emphasizing the contribution of molecular biology and genomics to phylogenetic reconstruction methods. | ||||
Author
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Publication Date | 2007/2007 | |||
Bibliographic Information 833 pp., color illus., glossary, index | ||||
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Evolution: The Molecular Landscape Evolution: The Molecular Landscape |
Title Evolution: The Molecular Landscape
Unique URL not available | ||||
ISBN | 978-087969870-6 | |||
Price | $310 | |||
Series Information: | ||||
This volume is based on presentations by the world-renowned investigators who gathered at the 74th annual Cold Spring Harbor Symposium on Quantitative Biology to celebrate the 150th anniversary of the publication of Charles Darwin’s On the Origin of Species. It reviews the latest advances in research into evolution, focusing on the molecular bases for evolutionary change. The topics covered include the appearance of the first genetic material, the origins of cellular life, evolution and development, selection and adaptation, and genome evolution. Human origins, cognition, and cultural evolution are also covered, along with social interactions. The line-up of speakers comprised a stellar list of preeminent scientists and thinkers such as the zoologist and prolific author E. O. Wilson (Harvard University); Jack W. Szostak (Harvard Medical School), a 2009 Nobel Prize winner who studies the chemistry of life's origins; and Nobel Prize winner and former president of HHMI Thomas Cech (Colorado Institute for Molecular Biotechnology), to name just a few. A complete summary of the meeting can be found here. | ||||
Editor
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Publication Date | 2009/2009 | |||
Bibliographic Information 485 pp., illus. 121 color; 86 b/w, indexes Trim size: 7-3/4" x 10-3/4" | ||||
Set Info | ||||
Topics |
Title Evolution: The Molecular Landscape
Unique URL http://www.cshlpress.com/link/evoML.htm | ||||
ISBN | 978-087969870-6 | |||
Price | $310 | |||
Series Information: | ||||
This volume is based on presentations by the world-renowned investigators who gathered at the 74th annual Cold Spring Harbor Symposium on Quantitative Biology to celebrate the 150th anniversary of the publication of Charles Darwin’s On the Origin of Species. It reviews the latest advances in research into evolution, focusing on the molecular bases for evolutionary change. The topics covered include the appearance of the first genetic material, the origins of cellular life, evolution and development, selection and adaptation, and genome evolution. Human origins, cognition, and cultural evolution are also covered, along with social interactions. The line-up of speakers comprised a stellar list of preeminent scientists and thinkers such as the zoologist and prolific author E. O. Wilson (Harvard University); Jack W. Szostak (Harvard Medical School), a 2009 Nobel Prize winner who studies the chemistry of life's origins; and Nobel Prize winner and former president of HHMI Thomas Cech (Colorado Institute for Molecular Biotechnology), to name just a few. A complete summary of the meeting can be found here. | ||||
Editor
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Publication Date | 2009/2009 | |||
Bibliographic Information 485 pp., illus. 121 color; 86 b/w, indexes Trim size: 7-3/4" x 10-3/4" | ||||
Set Info | ||||
Topics |
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Related Products |
Evolution: The Molecular Landscape Evolution |
Title Evolution: The Molecular Landscape
Unique URL http://www.cshlpress.com/link/evoMLp.htm | ||||
ISBN | 978-087969871-3 | |||
Price | $126 | |||
Series Information: | ||||
This volume is based on presentations by the world-renowned investigators who gathered at the 74th annual Cold Spring Harbor Symposium on Quantitative Biology to celebrate the 150th anniversary of the publication of Charles Darwin’s On the Origin of Species. It reviews the latest advances in research into evolution, focusing on the molecular bases for evolutionary change. The topics covered include the appearance of the first genetic material, the origins of cellular life, evolution and development, selection and adaptation, and genome evolution. Human origins, cognition, and cultural evolution are also covered, along with social interactions. The line-up of speakers comprised a stellar list of preeminent scientists and thinkers such as the zoologist and prolific author E. O. Wilson (Harvard University); Jack W. Szostak (Harvard Medical School), a 2009 Nobel Prize winner who studies the chemistry of life's origins; and Nobel Prize winner and former president of HHMI Thomas Cech (Colorado Institute for Molecular Biotechnology), to name just a few. A complete summary of the meeting can be found here. | ||||
Editor
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Publication Date | 2009/2009 | |||
Bibliographic Information 485 pp., illus. 121 color; 86 b/w, indexes Trim size: 7-3/4" x 10-3/4" | ||||
Set Info | ||||
Topics |
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Related Products |
Evolution: The Molecular Landscape Evolution |
Title Experimental Design for Biologists, Second Edition
Unique URL http://www.cshlpress.com/link/exdsnbio2.htm | ||||
ISBN | 978-1-621820-41-3 | |||
Price | $45 | |||
Series Information: | ||||
The effective design and analysis of experiments in biology are critical to success, yet graduate students in biological and medical sciences typically receive very little formal training in these steps. With feedback from readers of the first edition, colleagues, and students taking the very popular experimental design courses taught by the author, this second edition of Experimental Design for Biologists retains the engaging writing style while organizing the book around the four elements of experimental design: the framework, the system, the experiment, and the model. The approach has been tested in the classroom, where the author has taught numerous graduate students, MD/PhD students, and postdoctoral fellows. The goal of every scientist is to discover something new and with the aid of Experimental Design for Biologists, this task is made a little easier. This handbook explains how to establish the framework for an experimental project, how to set up all of the components of an experimental system, design experiments within that system, determine and use the correct set of controls, and formulate models to test the veracity and resiliency of the data. This thoroughly updated edition of Experimental Design for Biologists is an essential source of theory and practical guidance for designing a research plan. | ||||
Author
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Publication Date | 2014/2014 | |||
Bibliographic Information 304 pp., illus. (34 B&W), index | ||||
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Title Experimental Heart: A Novel
Unique URL http://www.cshlpress.com/link/exheartp.htm | ||||
ISBN | 978-087969876-8 | |||
Price | $15.00 | |||
Series Information: | ||||
Andy O'Hara, a post-doctoral researcher in a London cancer research institute, agrees to help an attractive colleague, Gina, who is collaborating with a pharmaceutical company. She is working on a virus-based vaccine but has discovered the company is planning a clinical trial of the vaccine in Africa without preliminary animal tests. Andy gets a tip-off that Gina's corporate collaborator has a shady past, but also discovers a scientific reason why the vaccine may be doomed to failure. As this excerpt begins, Andy and his friend Christine have helped Gina set up an illicit mouse experiment in their own animal facility, a move that could end all their careers if discovered. Read an excerpt here. — | ||||
Author
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Publication Date | 2009/2009 | |||
Bibliographic Information 364 pp. | ||||
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Related Products |
The Honest Look |
Title Faces of the Genome
Unique URL http://www.cshlpress.com/link/facesgenome.htm | ||||
ISBN | 978-1-621822-93-6 | |||
Price | $29 | |||
Series Information: | ||||
This book celebrates scientists who are explorers of the vast arrays of genes (“genomes”) that underpin the biology of humans and every other organism. The drawings are by the renowned Australian artist, Lewis Miller. Each is accompanied by an essay on the accomplishments and personality of the sitter, written by another distinguished scientist. This book portrays, in pencil and prose, 62 outstanding scientists who have had an extraordinary influence on our current understanding of biology, evolution, and medical science. | ||||
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Publication Date | 2018/2018 | |||
Bibliographic Information 131 pages, illustrated (62 color), index | ||||
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Topics |
Title Father to Son: Truth, Reason, and Decency
Unique URL http://www.cshlpress.com/link/fathertoson.htm | ||||
ISBN | 978-1-621820-35-2 | |||
Price | $29 | |||
Series Information: | ||||
At the age of 24, James Watson had a scientific discovery to his credit—the structure of DNA—that would win a Nobel Prize and forever change our understanding of genes and inheritance. Now, after a lifetime of accomplishment in research, writing, education, and science advocacy, Watson has delved for the first time publicly into his own lineage to chronicle an archetypical American family from before the Civil War to Vietnam. With its portraits of many memorable characters, illustrated with previously unpublished photographs and period documents, Father To Son brilliantly illuminates the fundamental truth that who we become as individuals is determined by both our genetic and cultural heritage.
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Author
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Publication Date | 2014/2014 | |||
Bibliographic Information 285 pages, illustrated, dust jacket | ||||
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Topics |
Title Fission Yeast: A Laboratory Manual
Unique URL http://www.cshlpress.com/link/fissionyeast.htm | ||||
ISBN | 978-1-621820-81-9 | |||
Price | $150 | |||
Series Information: | ||||
Fission yeast are unicellular, rod-shaped fungi that divide by medial fission. Studies using fission yeast were instrumental in identifying fundamental mechanisms that govern cell division, differentiation, and epigenetics, to name but a few. Their rapid growth rate, genetic malleability, and similarities to more complex eukaryotes continue to make them excellent subjects for many biochemical, molecular, and cell biological studies. This laboratory manual provides an authoritative collection of core experimental procedures that underpin modern fission yeast research. The contributors describe basic methods for culturing and genetically manipulating fission yeast, synchronization strategies for probing the cell cycle, technologies for assessing proteins, metabolites, and cell wall constituents, imaging methods to visualize subcellular structures and dynamics, and protocols for investigating chromatin and nucleic acid metabolism. Modifications to techniques commonly used in related species (e.g., budding yeast) are noted, as are useful resources for fission yeast researchers, including various databases and repositories. The well-studied fission yeast Schizosaccharomyces pombe is the focus throughout, but the emerging model S. japonicus—a larger, dimorphic species with several desirable characteristics—is also covered. This manual is an important reference for existing fission yeast laboratories and will serve as an essential start-up guide for those working with fission yeast for the first time. | ||||
Editor
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Publication Date | 2016/2016 | |||
Bibliographic Information 490 pages, illustrated (32 color, 17 B&W), index | ||||
Set Info | ||||
Topics |
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Related Products |
Fission Yeast: A Laboratory Manual |
Title Fission Yeast: A Laboratory Manual
Unique URL http://www.cshlpress.com/link/fissionyeastp.htm | ||||
ISBN | 978-1-621820-82-6 | |||
Price | $90 | |||
Series Information: | ||||
Fission yeast are unicellular, rod-shaped fungi that divide by medial fission. Studies using fission yeast were instrumental in identifying fundamental mechanisms that govern cell division, differentiation, and epigenetics, to name but a few. Their rapid growth rate, genetic malleability, and similarities to more complex eukaryotes continue to make them excellent subjects for many biochemical, molecular, and cell biological studies. This laboratory manual provides an authoritative collection of core experimental procedures that underpin modern fission yeast research. The contributors describe basic methods for culturing and genetically manipulating fission yeast, synchronization strategies for probing the cell cycle, technologies for assessing proteins, metabolites, and cell wall constituents, imaging methods to visualize subcellular structures and dynamics, and protocols for investigating chromatin and nucleic acid metabolism. Modifications to techniques commonly used in related species (e.g., budding yeast) are noted, as are useful resources for fission yeast researchers, including various databases and repositories. The well-studied fission yeast Schizosaccharomyces pombe is the focus throughout, but the emerging model S. japonicus—a larger, dimorphic species with several desirable characteristics—is also covered. This manual is an important reference for existing fission yeast laboratories and will serve as an essential start-up guide for those working with fission yeast for the first time. | ||||
Editor
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Publication Date | 2016/2016 | |||
Bibliographic Information 490 pages, illustrated (32 color, 17 B&W), index | ||||
Set Info | ||||
Topics |
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Related Products |
Fission Yeast: A Laboratory Manual |
Title Fly Pushing: The Theory and Practice of Drosophila Genetics, Second Edition
Unique URL http://www.cshlpress.com/link/fly2.htm | ||||
ISBN | 978-1621822-33-2 | |||
Price | $65 | |||
Series Information: | ||||
A second edition of the classic handbook has become a standard in the Drosophila field. This edition is expanded to include topics in which classical genetic strategies have been augmented with new molecular tools. Included are such new techniques as homologous recombination, RNAi, new mapping techniques, and new mosaic marking techniques. | ||||
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Publication Date | 2004/2004 | |||
Bibliographic Information 191 pp., illus., appendices, index | ||||
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Related Products |
An Introduction to Nervous Systems An Introduction to Nervous Systems Invertebrate Neurobiology |
Title Francis Crick: Hunter of Life's Secrets
Unique URL http://www.cshlpress.com/link/crick.htm | ||||
ISBN | 978-087969798-3 | |||
Price | $46.00 | |||
Series Information: | ||||
This engrossing biography by one of molecular biology’s foremost scholars reveals the remarkable evolution of Francis Crick’s scientific career and the shaping of his personality. From unpromising beginnings, he became a vital contributor to a remarkably creative period in science. Olby chronicles Crick’s life from his early studies in biophysics, to the discovery of the structure of DNA, to his later work in neuroscience and the nature of consciousness. This account is woven together with insights into his personal life gained through access to Crick’s papers, family, and friends. Robert Olby’s book is a richly detailed portrait of one of the great scientists of our time. About the author: Robert Olby, a prominent historian of science, is research professor in the Department of History and Philosophy of Science at the University of Pittsburgh and author of the highly regarded Origins of Mendelism (1966, 1985) and The Path to the Double Helix (1974, 1994). He has published and lectured widely on 19th and 20th century topics in biology, genetics, and molecular biology. Olby is a member of the History of Science Society and the International Academy of the History of Science. | ||||
Author
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Publication Date | 2009/2009 | |||
Bibliographic Information 538 pp, illus., indexes | ||||
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Topics |
Title Function and Dysfunction of the Cochlea: From Mechanisms to Potential Therapies
Unique URL http://www.cshlpress.com/link/funcdyscochlea.htm |