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Correcting the Blueprint of Life: An Historical Account of the Discovery of DNA Repair Mechanisms

Subject Area(s):  Molecular BiologyBiochemistryHistory of Science

© 1997 • 210 pp., illus., index
Cloth •
ISBN  978-087969507-1

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  •     Description    
  •     Contents    
  •     Reviews    


In this brief, readable, and revealing book, one of the pioneers of the now rapidly evolving field of DNA repair traces the history of the discovery of the more important mechanisms by which cells respond to DNA damage. Errol Friedberg has written an enjoyable and informative introduction to the study of DNA mutagenesis and re-pair that will interest students at an advanced undergraduate or graduate student level as well as investigators in fields as diverse as oncogenesis, cell cycle regulation, transcription and DNA replication.


CHAPTER 1: In the Beginning

CHAPTER 2: Let There Be Light: The Discovery of Enzymatic Photoreactivation

CHAPTER 3: The Emergence of Excision Repair

CHAPTER 4: New Mechanisms for Repairing DNA

CHAPTER 5: Mismatched Bases Are Repaired by Yet a Different Mode

CHAPTER 6: The Remarkable SOS Phenomenon

CHAPTER 7: Epilogue: Molecule of the Year 1994



review:  "Friedberg provides a real inspiration by recounting some of the rich experiences that the scientific life can offer. We are treated to descriptions of sudden flashes of insight over a dram of whisky at a conference in the Scottish highlands, pivotal blackboard discussions with students, and colleagues taking Sunday afternoon walks while planning experiments and searching for fossils….

For those currently investigating DNA repair, this fluent account is essential reading, and would also be a fine complement to courses on the history of molecular biology."