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Enteric Hepatitis Viruses

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Infectious DiseasesHuman Biology and DiseaseViruses

Edited by Stanley M. Lemon, University of North Carolina at Chapel Hill; Christopher M. Walker, The Research Institute at Nationwide Children's Hospital

Download a Free Excerpt from Enteric Hepatitis Viruses:

HAV and HEV: Emerging and Re-emerging Enterically Transmitted Hepatitis Viruses

© 2018 • 400 pages, illustrated (69 color and 24 B&W), index
Hardcover •
ISBN  978-1-621821-62-5

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  •     Description    
  •     Contents    
  •     Reviews    


Viruses that are transmitted via the fecal–oral route and may cause liver damage are known as enteric hepatitis viruses. These viruses, which include the hepatitis A and E viruses (HAV and HEV, respectively), infect millions of individuals worldwide and pose significant threats to public health.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines recent progress in our understanding of the biology and pathogenic mechanisms of HAV and HEV, as well as prospects for improving their control. Contributors explore the molecular characteristics and life cycles of HAV and HEV, their interactions with the liver and immune system, the clinical manifestations of the infections they cause, and their transmission via contaminated food and water. Additional topics include the geographic distributions of the various HAV and HEV genotypes, factors that influence their changing epidemiology, and the development of effective vaccines and vaccination strategies.

The authors also discuss advances in cell-culture systems and animal models, as well as how studies of HAV and HEV may provide insight into other viruses and infectious diseases of the liver. This volume is therefore an essential reference for all virologists, immunologists, pathologists, clinicians, and public health professionals.


Hepatitis A Virus and Hepatitis E Virus: Emerging and Re-Emerging Enterically Transmitted Hepatitis Viruses
Stanley M. Lemon and Christopher M. Walker
History of the Discovery of Hepatitis A Virus
Stephen M. Feinstone
Enterically Transmitted Non-A, Non-B Hepatitis and the Discovery of Hepatitis E Virus
Stanley M. Lemon and Christopher M. Walker
Classification and Genomic Diversity of Enterically Transmitted Hepatitis Viruses
Donald B. Smith and Peter Simmonds
Hepatitis A Virus Genome Organization and Replication Strategy
Kevin L. McKnight and Stanley M. Lemon
Hepatitis A Virus Codon Usage: Implications for Translation Kinetics and Capsid Folding
Rosa M. Pintó, Francisco-Javier Pérez-Rodríguez, Lucia D’Andrea, Montserrat de Castellarnau, Susana Guix, and Albert Bosch
Hepatitis A Virus Capsid Structure
David I. Stuart, Jingshan Ren, Xiangxi Wang, Zihe Rao, and Elizabeth E. Fry
Hepatitis E Virus Genome Structure and Replication Strategy
Scott P. Kenney and Xiang-Jin Meng
Evolutionary Origins of Enteric Hepatitis Viruses
Anna-Lena Sander, Victor Max Corman, Alexander N. Lukashev, and Jan Felix Drexler
Stem Cell–Derived Culture Models of Hepatitis E Virus Infection
Viet Loan Dao Thi, Xianfang Wu, and Charles M. Rice
Murine Models of Hepatitis A Virus Infection
Asuka Hirai-Yuki, Jason K. Whitmire, Michael Joyce, D. Lorne Tyrrell, and Stanley M. Lemon
Small Animal Models of Hepatitis E Virus Infection
Tian-Cheng Li and Takaji Wakita
Nonhuman Primate Models of Hepatitis A Virus and Hepatitis E Virus Infections
Robert E. Lanford, Christopher M. Walker, and Stanley M. Lemon
Comparative Pathology of Hepatitis A Virus and Hepatitis E Virus Infection
John M. Cullen and Stanley M. Lemon
Globalization and the Changing Epidemiology of Hepatitis A Virus
Kathryn H. Jacobsen
Epidemiology and Transmission of Hepatitis A Virus and Hepatitis E Virus Infections in the United States
Megan G. Hofmeister, Monique A. Foster, and Eyasu H. Teshale
Epidemiology of Genotype 1 and 2 Hepatitis E Virus Infections
Kenrad E. Nelson, Alain B. Labrique, and Brittany L. Kmush
Transmission and Epidemiology of Hepatitis E Virus Genotype 3 and 4 Infections
Harry R. Dalton and Jacques Izopet
Natural History, Clinical Manifestations, and Pathogenesis of Hepatitis A
Eui-Cheol Shin and Sook-Hyang Jeong
Natural History, Clinical Manifestations, and Pathogenesis of Hepatitis E Virus Genotype 1 and 2 Infections
Rakesh Aggarwal and Amit Goel
Acute and Persistent Hepatitis E Virus Genotype 3 and 4 Infection: Clinical Features, Pathogenesis, and Treatment
Nassim Kamar and Sven Pischke
Innate Immunity to Enteric Hepatitis Viruses
Zongdi Feng and Stanley M. Lemon
Adaptive Immune Responses in Hepatitis A Virus and Hepatitis E Virus Infections
Christopher M. Walker
Immunization against Hepatitis A
Daniel Shouval
Immunization against Hepatitis E
Bruce L. Innis and Julia A. Lynch


review:  “This book provides a state-of-the-art overview of HAV and HEV research and will be of interest to all virologists, particularly those working on riboviruses and anyone engaged in hepatitis research.”
      —Quarterly Review of Biology