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Cell Survival and Cell Death

Subject Area(s):  Developmental BiologyCell BiologyMolecular BiologyImmunology and Vaccines

Edited by Eric H. Baehrecke, University of Massachusetts; Douglas R. Green, St. Jude Children's Research Hospital; Sally Kornbluth, Duke University; Guy S. Salvesen, Sanford-Burnham Medical Research Institute

© 2013 • 380 pp., illus. (59 4C, 25 B&W), index
Hardcover • $135 94.50
ISBN  978-1-936113-31-6
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Billions of cells die every day in the human body. This is required for normal development and physiology, as well as the elimination of errant cells. Apoptosis and other cell death mechanisms are complex and carefully controlled. If cell death does not occur when it should, cancer and other diseases may develop.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of apoptosis, autophagy, and necrosis. Contributors describe in detail the molecular mechanisms of cell death signaling, including death receptor-ligand systems, BCL-2 family proteins, mitochondrial permeabilization, the endocytic pathway, caspases, and signals that trigger the clearance of dying cells. Survival mechanisms and proteins such as IAPs that antagonize cell death are also described.

This volume includes discussion of tumor suppression, the altered metabolism of cancer cells, and the development of therapeutic drugs. It is an essential reference for cell and developmental biologists, cancer biologists, and all who want to understand when and how cell death is required for life.


Evolution of the Animal Apoptosis Network
Christian M. Zmasek and Adam Godzik
Caspase Functions in Cell Death and Disease
David R. McIlwain, Thorsten Berger, and Tak W. Mak
Apoptotic and Nonapoptotic Caspase Functions in Animal Development
Masayuki Miura
Cellular Mechanisms Controlling Caspase Activation and Function
Amanda B. Parrish, Christopher D. Freel, and Sally Kornbluth
Caspase Substrates and Inhibitors
Marcin Poręba, Aleksandra Stróżyk, Guy S. Salvesen, and Marcin Drag
Death Receptor-Ligand Systems in Cancer, Cell Death, and Inflammation
Henning Walczak
Mitochondrial Regulation of Cell Death
Stephen W.G. Tait and Douglas R. Green
Mechanisms of Action of Bcl-2 Family Proteins
Aisha Shamas-Din, Justin Kale, Brian Leber, and David W. Andrews
Multiple Functions of BCL-2 Family Proteins
J. Marie Hardwick and Lucian Soane
Inhibitor of Apoptosis (IAP) Proteins—Modulators of Cell Death and Inflammation
John Silke and Pascal Meier
Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion
Amelia Hochreiter-Hufford and Kodi S. Ravichandran
The Endolysosomal System in Cell Death and Survival
Urška Repnik, Maruša Hafner Česen, and Boris Turk
Metabolic Stress in Autophagy and Cell Death Pathways
Brian J. Altman and Jeffrey C. Rathmell
mTOR-Dependent Cell Survival Mechanisms
Chien-Min Hung, Luisa Garcia-Haro, Cynthia A. Sparks, and David A. Guertin
Oncogenes in Cell Survival and Cell Death
Jake Shortt and Ricky W. Johnstone
The Role of the Apoptotic Machinery in Tumor Suppression
Alex R.D. Delbridge, Liz J. Valente, and Andreas Strasser
The Role of Apoptosis-Induced Proliferation for Regeneration and Cancer
Hyung Don Ryoo and Andreas Bergmann
Fueling the Flames: Mammalian Programmed Necrosis in Inflammatory Diseases
Francis Ka-Ming Chan
Regulation and Function of Autophagy during Cell Survival and Cell Death
Gautam Das, Bhupendra V. Shravage, and Eric H. Baehrecke
Autophagy and Cancer
Li Yen Mah and Kevin M. Ryan
Autophagy and Neuronal Cell Death in Neurological Disorders
Ralph A. Nixon and Dun-Sheng Yang

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