Description

Epithelial ovarian cancer (EOC) is among the most lethal gynecologic malignancies, claiming lives worldwide. It is often diagnosed late, recurs frequently, and resists long-term control. Despite decades of progress in molecular profiling, targeted therapeutics, and detection technologies, the complexity of EOC continues to challenge clinicians and researchers.

This landmark volume brings together leaders in oncology, developmental biology, molecular pathology, and translational medicine to provide a comprehensive, integrated account of the biology, pathogenesis, prevention, detection, and treatment of ovarian cancer.

Highlights include:

• A reframing of EOC’s origins through insights from developmental biology and embryology
• Analyses of distinct histotypes—high-grade serous, low-grade serous, mucinous, and clear cell carcinomas—that reveal vulnerabilities and therapeutic opportunities
• Advances in preclinical models, from engineered mice to organoids
• Explorations of genomic instability, immune environments, and mutational processes that drive therapeutic resistance
• Updates on prevention, early detection, and systemic therapies, including immunotherapies

Ovarian cancer is not a single disease but a spectrum of distinct malignancies requiring tailored approaches. Ovarian Cancer is an essential reference volume for oncologists, biomedical researchers, and trainees that will assist the multidisciplinary collaborations necessary to improve patient outcomes.