Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults

Click to Enlarge				Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults Book Series: A Cold Spring Harbor Perspectives in Medicine Collection Subject Area(s): Genomics; Genetics; Immunology and Vaccines; Cancer Biology Edited by Alejandro Gutierrez, St. Jude Children’s Research Hospital; Alex Kentsis, Memorial Sloan Kettering Cancer Center

				Due February 2025 • 17 chapters, illustrated (38 color), index Hardcover • ISBN 978-1-621825-05-0

Description Contents Description A variety of cancers affect children and young adults, including leukemias, sarcomas, and tumors of the nervous system. These are caused by errors that occur during development and arise in specific populations of cells that accumulate somatic mutations in early life. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of our understanding of cancers that occur during childhood and in young adults, the mechanisms underlying their appearance, and current and future treatment strategies. Recent discoveries show these young-onset cancers are fundamentally developmental in origin. The contributors review how developmental processes in the growing body generate cell states that are susceptible to tumorigenesis in particular types of cells. They discuss the bases for genetic predisposition, endogenous and exogenous somatic mutational processes, epigenetic regulation, and the influence of the immune and tissue microenvironments. In addition, the authors examine the multiple therapeutic approaches used to target young-onset cancers, such as combination treatments and immunologic, metabolic, and cellular therapies. Cancer surveillance is also covered, as well as the unique challenges of pediatric cancer drug development. The volume will therefore be an essential reference for cancer biologists, practicing oncologists, and those interested in how we can drive progress in cancer treatment. Contents Preface Toward a Unified Theory of Why Young People Develop Cancer Alex Kentsis Genetic Predisposition to Hematologic Malignancies Kayla V. Hamilton, Akiko Shimamura, and Jessica A. Pollard New Paradigms in the Clinical Management of Li–Fraumeni Syndrome Camilla Giovino, Vallijah Subasri, Frank Telfer, and David Malkin Developmental Dysregulation of Childhood Cancer Thomas R.W. Oliver and Sam Behjati Developmental Modeling of Childhood Cancers Kosuke Funato and Viviane Tabar Developmental Heterogeneity of Rhabdomyosarcoma Bradley T. Stevens and Mark E. Hatley Targeting Hyperactive Ras Signaling in Pediatric Cancer Anya Levinson, Kevin Shannon, and Benjamin J. Huang Parallels in Canonical Developmental Signaling Pathways between Normal Development and the Tumor Microenvironment Julia Segal, James Cronk, Brendan Ball, Greta Forbes, Kailey Jackett, Kathy Li, Alondra Martinez Osorno, Emily San Andres Montalvan, Alice Browne, Jessica Lake, and Rosandra N. Kaplan Osteosarcoma through the Lens of Bone Development, Signaling, and Microenvironment Elizabeth P. Young, Amanda E. Marinoff, Eunice Lopez-Fuentes, and E. Alejandro Sweet-Cordero Lineage-Selective Dependencies in Pediatric Cancers K. Elaine Ritter and Adam D. Durbi Immunotherapies for Childhood Cancer Jeong A. Park and Nai-Kong V. Cheung Acute Promyelocytic Leukemia, Retinoic Acid, and Arsenic: A Tale of Dualities Domitille Rérolle, Hsin-Chieh Wu, and Hugues de Thé Principles in the Development of Contemporary Treatment of Childhood Malignancies: The First 75 Years Katie A. Greenzang and Stephen E. Sallan Cancer Therapies Targeting Cellular Metabolism Benjamin Morris and Alejandro Gutierrez Adoptive Cell Therapy for Pediatric Solid Tumors Amy B. Hont and Catherine M. Bollard Epigenetic Therapies Wallace Bourgeois, Scott A. Armstrong, and Emily B. Heikamp Pediatric Cancer Drug Development: Leveraging Insights in Cancer Biology and the Evolving Regulatory Landscape to Address Challenges and Guide Further Progress Rosane Charlab, Ruby Leong, Stacy S. Shord, and Gregory H. Reaman Index

Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults

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