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Targeting Cancer

(Cold Spring Harbor Symposia on Quantitative Biology LXXXI)

Subject Area(s):  GenomicsMolecular BiologyGeneticsImmunology and VaccinesCancer Biology

Edited by David Stewart, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory

Foreword and Contents
Sample Conversation with Elaine Mardis
Sample Conversation with David Tuveson
Sample Conversation with Harold Varmus

© 2017 • 368 pages, illustrated (96 color and 79 B&W), index
Paperback • $129 103.20
ISBN  978-1-621822-10-3
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The 81st Cold Spring Harbor Symposium focused on Targeting Cancer. The implications of how the underlying science can drive improvements in diagnostic, prognostic, and therapeutic approaches was a major theme throughout the Symposium. The topics covered at the meeting included: Cancer Genes and Genomes; Cancer Pathways; Tumor Cell Biology; Cancer Growth & Progression; Innate & Adaptive Immune Responses; and Enabling Technologies. Several speakers participated in interviews during the course of the Symposium week and transcripts of those videos and the Dorcas Cummings lecture are included.


Symposium Participants
Cancer Stem Cells

Normal and Neoplastic Stem Cells
Melissa N. McCracken, Benson M. George, Kevin S. Kao, Kristopher D. Marjon, Tal Raveh, and Irving L. Weissman

Targeting the Epithelial-to-Mesenchymal Transition: The Case for Differentiation-Based Therapy
Diwakar R. Pattabiraman and Robert A. Weinberg

Trimming the Vascular Tree in Tumors: Metabolic and Immune Adaptations
Elizabeth Allen, Rindert Missiaen, and Gabriele Bergers

Cell of Origin and Cancer Stem Cells in Tumor Suppressor Mouse Models of Glioblastoma
Sheila R. Alcantara Llaguno, Xuanhua Xie, and Luis F. Parada

Genetics and Epigenetics

The Enigma of p53
Guillermina Lozano

Alterations in Three-Dimensional Organization of the Cancer Genome and Epigenome
Joanna Achinger-Kawecka, Phillippa C. Taberlay, and Susan J. Clark

Composition and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease
John L. Pulice and Cigall Kadoch

The Essential Transcriptional Function of BRD4 in Acute Myeloid Leukemia
Jae-Seok Roe and Christopher R. Vakoc


Reexamining How Cancer Cells Exploit the Body's Metabolic Resources
Craig B. Thompson and Wilhelm Palm

Autophagy, Metabolism, and Cancer
Jessie Yanxiang Guo and Eileen White

A Time for MYC: Metabolism and Therapy
Chi V. Dang

Beyond the Oncogene Revolution: Four New Ways to Combat Cancer
Thorsten Berger, Mary E. Saunders, and Tak W. Mak

Lipid Synthesis Is a Metabolic Liability of Non-Small Cell Lung Cancer
Robert U. Svensson and Reuben J. Shaw

Targets, Vaccines, and Therapeutics

Cancer Immunogenomics: Computational Neoantigen Identification and Vaccine Design
Jasreet Hundal, Christopher A. Miller, Malachi Griffith, Obi L. Griffith, Jason Walker, Susanna Kiwala, Aaron Graubert, Joshua McMichael, Adam Coffman, and Elaine R. Mardis

Targeting HIF2 in Clear Cell Renal Cell Carcinoma
Hyejin Cho and William G. Kaelin

BET Bromodomain Proteins as Cancer Therapeutic Targets
Shaokun Shu and Kornelia Polyak

To Prime, or Not to Prime: That Is the Question
Danielle S. Potter and Anthony Letai

Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer
Stefano Annunziato, Marco Barazas, Sven Rottenberg, and Jos Jonkers

Microenvironment and Metastasis

Tumor-Stroma Interactions in Bone Metastasis: Molecular Mechanisms and Therapeutic Implications
Hanqiu Zheng, Wenyang Li, and Yibin Kang

Cancer, Oxidative Stress, and Metastasis
Jennifer G. Gill, Elena Piskounova, and Sean J. Morrison

RON Signaling Is a Key Mediator of Tumor Progression in Many Human Cancers
Najme Faham 
and Alana L. Welm

Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis
Madeleine J. Oudin and Valerie M. Weaver

Models of Cancer

Pathways Involved in Formation of Mammary Organoid Architecture Have Keys to Understanding Drug Resistance and to Discovery of Druggable Targets
Saori Furuta and Mina J. Bissell

Explaining the Paucity of Intratumoral T Cells: A Construction Out of Known Entities
Douglas T. Fearon

Modeling Breast Cancer Intertumor and Intratumour Heterogeneity Using Xenografts
Alejandra Bruna, Oscar M. Rueda, and Carlos Caldas

Challenges and Opportunities in Modeling Pancreatic Cancer
Michael E. Feigin and David A. Tuveson

Cancer Genomics and Tumor Heterogeneity

Functional Genomic Characterization of Cancer Genomes
Thomas P. Howard, Francisca Vazquez, Aviad Tsherniak, Andrew L. Hong, Mik Rinne, Andrew J. Aguirre, 
Jesse S. Boehm, and William C. Hahn

How Cancer Genomics Drives Cancer Biology: Does Synthetic Lethality Explain Mutually 
Exclusive Oncogenic Mutations?
Harold Varmus, Arun M. Unni, and 
William W. Lockwood

A Pipeline for Drug Target Identification and Validation
Eusebio Manchado, Chun-Hao Huang, Nilgun Tasdemir, Darjus F. Tschaharganeh, John E. Wilkinson, and Scott W. Lowe

Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity
David T. Miyamoto, David T. Ting, Mehmet Toner, Shyamala Maheswaran, and Daniel A. Haber

Discovery of Double-Stranded Genomic DNA in Circulating Exosomes
Raghu Kalluri and 
Valerie S. LeBleu


Moving Closer to Victory
Taru Muranen and Joan S. Brugge

Dorcas Cummings Lecture

Charles Sawyers
Conversations at the Symposium

Gabriele Bergers

Joan Brugge

Karen Cichowski

Susan Clark

Gerard Evan

Daniel Haber

William Kaelin

Raghu Kalluri

Scott Lowe

Guillermina (Gigi) Lozano

David Lyden

Elaine Mardis

Sean Morrison

Benjamin Neel

Luis Parada

Sir Michael Stratton

David Tuveson

Christopher Vakoc

Harold Varmus

Karen Vousden

Valerie Weaver

Robert Weinberg

Eileen White

Author Index
Subject Index