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Addiction, Second Edition

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Cognition and BehaviorHuman Biology and DiseaseNeurobiology

Edited by R. Christopher Pierce, Rutgers University Robert Wood Johnson Medical School; Ellen M. Unterwald, Lewis Katz School of Medicine at Temple University; Paul J. Kenny, Icahn School of Medicine at Mount Sinai

Download a Free Excerpt from Addiction, Second Edition:

The Persistent Challenge of Developing Addiction Pharmacotherapies

© 2020 • 404 pages, illustrated (16 color and 9 B&W), index
Hardcover •
ISBN  978-1-621823-50-6

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  •     Description    
  •     Contents    


Addiction to psychoactive drugs found in cigarettes, alcoholic drinks, and opioid analgesics is a severe problem for society. Events associated with addiction—drug abuse, dependence, withdrawal, and relapse—involve complex neurobiological changes in the brain. To develop effective long-term treatment strategies for substance use disorders, a more complete understanding of these brain changes is needed.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive update on our understanding of the biological basis of and treatment strategies for addiction to psychoactive drugs, with an emphasis on opioids. Contributors examine the molecular targets of alcohol, cannabinoids, nicotine, stimulants, and opioids, the resulting changes to the neurocircuitry, and various genetic, environmental, developmental, and behavioral factors that influence the progression from abuse to addiction and susceptibility to relapse. Advances in animal models of addictive behavior and single-cell strategies to dissect neural circuits are also described.

In addition, the authors review compounds currently used or under development to treat substance use disorders, their pharmacological mechanisms, and challenges related to preclinical testing in animal models. This volume is an indispensable reference for all neuroscientists and those who are interested in understanding and reducing the public health burden of drug addiction.


The Persistent Challenge of Developing Addiction Pharmacotherapies
Sarah E. Swinford-Jackson, Charles P. O’Brien, Paul J. Kenny, Louk J.M.J. Vanderschuren, Ellen M. Unterwald, and R. Christopher Pierce
Animal Models of the Behavioral Symptoms of Substance Use Disorders
Louk J.M.J. Vanderschuren and Serge H. Ahmed
Neural Substrates and Circuits of Drug Addiction
Matthew W. Feltenstein, Ronald E. See, and Rita A. Fuchs
Developments from Bulk Optogenetics to Single-Cell Strategies to Dissect the Neural Circuits that Underlie Aberrant Motivational States
Jose Rodriguez-Romaguera, Vijay M.K. Namboodiri, Marcus L. Basiri, Alice M. Stamatakis, and Garret D. Stuber
Psychostimulant-Induced Adaptations in Nucleus Accumbens Glutamatergic Transmission
William J. Wright and Yan Dong
Epigenetics of Drug Addiction
Andrew F. Stewart, Sasha L. Fulton, and Ian Maze
Drug-Evoked Synaptic Plasticity of Excitatory Transmission in the Ventral Tegmental Area
Camilla Bellone, Michael Loureiro, and Christian Lüscher
Genetic Vulnerability to Opioid Addiction
Brian Reed and Mary Jeanne Kreek
Medications Development for Treatment of Opioid Use Disorder
E. Andrew Townsend, S. Stevens Negus, and Matthew L. Banks
Neonatal Opioid Withdrawal Syndrome (NOWS): A Transgenerational Echo of the Opioid Crisis
Andrew E. Weller, Richard C. Crist, Benjamin C. Reiner, Glenn A. Doyle, and Wade H. Berrettini
Consequences of Parental Opioid Exposure on Neurophysiology, Behavior, and Health in the Next Generations
Fair M. Vassoler and Mathieu E. Wimmer
Opioid-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area Dopamine Neurons
Marie A. Doyle and Michelle S. Mazei-Robison
Glutamatergic Systems and Memory Mechanisms Underlying Opioid Addiction
Jasper A. Heinsbroek, Taco J. De Vries, and Jamie Peters
Opioid Modulation of the Gut–Brain Axis in Opioid-Associated Comorbidities
Li Zhang and Sabita Roy
Mechanisms of Nicotine Addiction
Marina R. Picciotto and Paul J. Kenny
Translational Research in Nicotine Addiction
Miranda L. Fisher, James R. Pauly, Brett Froeliger, and Jill R. Turner
The Role of the Central Amygdala in Alcohol Dependence
Marisa Roberto, Dean Kirson, and Sophia Khom
Growth Factors and Alcohol Use Disorder
Mirit Liran, Nofar Rahamin, Dorit Ron, and Segev Barak
A Brain on Cannabinoids: The Role of Dopamine Release in Reward Seeking and Addiction
Kate Z. Peters, Erik B. Oleson, and Joseph F. Cheer
Impairment of Synaptic Plasticity by Cannabis, Δ9-THC, and Synthetic Cannabinoids
Alexander F. Hoffman, Eun-Kyung Hwang, and Carl R. Lupica