Click to Enlarge

Add To Cart


Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Microscopy and ImagingHuman Biology and DiseaseImmunology and VaccinesMicrobiology

Edited by Stefan H.E. Kaufmann, Max Planck Institute for Infection Biology; Eric Rubin, Harvard School of Public Health; Ali Zumla, University College London Medical School

Download Free Excerpts from Tuberculosis:

Preface and Contents
Cell-Autonomous Effector Mechanisms against Mycobacterium tuberculosis

© 2015 • 655 pp., illustrated (53 color, 73 B&W), index
Hardcover • $135 94.50
ISBN  978-1-621820-73-4
You save: 30%
You will receive free shipping on this item at checkout.
Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only.

  •     Description    
  •     Contents    
  •     Reviews    


Tuberculosis (TB) is a serious infectious disease of the lungs that is usually caused by the bacterium Mycobacterium tuberculosis. Nearly one-third of the world’s population is currently infected with latent TB, and millions of individuals develop the active, potentially fatal form of the disease each year. The continuing emergence and spread of drug-resistant TB strains is one of the most difficult challenges facing control of the disease.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines all aspects of M. tuberculosis biology, transmission, and infection, as well as ongoing strategies to treat and control it. Contributors explore the biological characteristics of M. tuberculosis, its complex interactions with the human immune system, and factors that influence the progression from latent to active TB disease (e.g., coinfection with HIV/AIDS). The clinical manifestations of TB, both pulmonary and extrapulmonary, are fully described and illustrated.

This volume also includes discussions of recent advances in the development of diagnostics, drugs, and vaccines, as well as strategies for enhanced implementation of existing interventions. It is an essential reference for microbiologists, immunologists, pathologists, epidemiologists, and clinicians, and all who wish to understand and combat this global health burden.


Cell-Autonomous Effector Mechanisms against Mycobacterium tuberculosis
John D. MacMicking
Manipulation of the Mononuclear Phagocyte System by Mycobacterium tuberculosis
Geanncarlo Lugo-Villarino and Olivier Neyrolles
Interaction of Mycobacterium tuberculosis with Host Cell Death Pathways
Lalitha Srinivasan, Sarah Ahlbrand, and Volker Briken
Autophagy in Tuberculosis
Vojo Deretic
Innate and Adaptive Cellular Immune Responses to Mycobacterium tuberculosis Infection
Katrin D. Mayer-Barber and Daniel L. Barber
Antigens for CD4 and CD8 T Cells in Tuberculosis
Cecilia S. Lindestam Arlehamn, David Lewinsohn, Alessandro Sette, and Deborah Lewinsohn
Nonclassical T Cells and Their Antigens in Tuberculosis
Gennaro De Libero, Amit Singhal, Marco Lepore, and Lucia Mori
Role of B Cells and Antibodies in Acquired Immunity against Mycobacterium tuberculosis
Jacqueline M. Achkar, John Chan, and Arturo Casadevall
Immunity and Immunopathology in the Tuberculous Granuloma
Antonio J. Pagán and Lalita Ramakrishnan
Novel Vaccination Strategies against Tuberculosis
Peter Andersen and Stefan H.E. Kaufmann
Toward a Unified Biosignature for Tuberculosis
Jeroen Maertzdorf, Stefan H.E. Kaufmann, and January Weiner III
Clinical Immunology and Multiplex Biomarkers of Human Tuberculosis
Gerhard Walzl, Mariëlle C. Haks, Simone A. Joosten, Léanie Kleynhans, Katharina Ronacher, and Tom H.M. Ottenhoff
Mouse Model of Tuberculosis
Andrea M. Cooper
Animal Models of Tuberculosis: Guinea Pigs
Simon Clark, Yper Hall, and Ann Williams
Animal Models of Tuberculosis: Zebrafish
Lisanne M. van Leeuwen, Astrid M. van der Sar, and Wilbert Bitter
Modeling Tuberculosis in Nonhuman Primates
Charles A. Scanga and JoAnne L. Flynn
Mycobacterial Growth
Iria Uhía, Kerstin J. Williams, Vahid Shahrezaei, and Brian D. Robertson
The Mycobacterial Cell Envelope–Lipids
Mary Jackson
The Mycobacterial Cell Wall–Peptidoglycan and Arabinogalactan
Luke J. Alderwick, James Harrison, Georgina S. Lloyd, and Helen L. Birch
Mycobacterium tuberculosis Metabolism
Digby F. Warner
Genetic Approaches to Facilitate Antibacterial Drug Development
Dirk Schnappinger
Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm
Sumit Chakraborty and Kyu Y. Rhee
The Tuberculosis Drug Discovery and Development Pipeline and Emerging Drug Targets
Khisimuzi Mdluli, Takushi Kaneko, and Anna Upton
Pharmacologic Considerations in Use and Development of Antituberculosis Drugs
Geraint Davies
Diversity and Evolution of Mycobacterium tuberculosis: Moving to Whole-Genome-Based Approaches
Stefan Niemann and Philip Supply
Host-Directed Therapies for Tuberculosis
David M. Tobin
Comparative Genomics of Mycobacteria: Some Answers, Yet More New Questions
Marcel A. Behr
Global Epidemiology of Tuberculosis
Philippe Glaziou, Charalambos Sismanidis, Katherine Floyd, and Mario Raviglione
Advances in Diagnostic Assays for Tuberculosis
Steven D. Lawn
Imaging in Tuberculosis
Jamshed B. Bomanji, Narainder Gupta, Parveen Gulati, and Chandan J. Das
Tuberculosis Treatment and Drug Regimens
Giovanni Sotgiu, Rosella Centis, Lia D’ambrosio, and Giovanni Battista Migliori
Diagnosis and Management of Latent Tuberculosis Infection
Laura Muñoz, Helen R. Stagg, and Ibrahim Abubakar
Clinical Aspects of Adult Tuberculosis
Robert Loddenkemper, Marc Lipman, and Alimuddin Zumla
Tuberculosis in Children
Ben J. Marais and H. Simon Schaaf
Multidrug-Resistant Tuberculosis and Extensively Drug-Resistant Tuberculosis
Kwonjune J. Seung, Salmaan Keshavjee, and Michael L. Rich
Tuberculosis and HIV Coinfection
Judith Bruchfeld, Margarida Correia-Neves, and Gunilla Källenius
Tuberculosis Comorbidity with Communicable and Noncommunicable Diseases
Matthew Bates, Ben J. Marais, and Alimuddin Zumla
Transmission and Institutional Infection Control of Tuberculosis
Edward A. Nardell


review:  “...this is a welcome addition to the library of tuberculosis textbooks. By providing a state-of-the-art review of present immunological thinking, the editors have provided a must-read for students and new entrants to the specialty. The book will also be of interest to tuberculosis clinicians and those concerned with drug discovery and vaccine research.”
      —The Lancet