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The Endoplasmic Reticulum, Second Edition

Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Cell BiologyMolecular BiologyBiochemistry

Edited by Susan Ferro-Novick, UC San Diego, School of Medicine; Tom Rapoport, Harvard Medical School; Randy Schekman, University of California at Berkeley

Due January 2023 • 300 pages (approx.), illustrated, index
Hardcover • $135
ISBN  978-1-621824-37-4

  •     Description    
  •     Contents    


The endoplasmic reticulum is an intracellular organelle that plays a critical role in processing of proteins and lipids in cells. This new edition updates our understanding of its structure, functions and transport mechanisms.


1) Beyond the Kennedy Pathway: Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum
Robert V. Farese Jr. and Tobias C. Walther
2) Endoplasmic Reticulum-Associated Protein Degradation
Logesvaran Krshnan, Michael L. van de Weijer, and Pedro Carvalho
3) The Role of Rhomboid Superfamily in ER Protein Quality Control: From Mechanisms and Functions to Diseases
Satarupa Bhaduri, Nicola Scott, and Sonya E. Neal
4) The Endoplasmic Reticulum and the Fidelity of Nascent Protein Localization
Michael J. McKenna and Sichen Shao
5) Mechanism of Protein Translocation by the Sec61 Translocon Complex
Samuel Itskanov and Eunyong Park
6) The Biogenesis of Multipass Membrane Proteins
Luka Smalinskaitė and Ramanujan S. Hegde
7) A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum
Alina Guna, Masami Hazu, Giovani Pinton Tomaleri, and Rebecca M. Voorhees
8) Post-Translational Regulation of HMG CoA Reductase
Youngah Jo and Russell A. DeBose-Boyd
9) Lipid Transport from Endoplasmic Reticulum to Autophagic Membranes
Takuo Osawa, Kazuaki Matoba, and Nobuo N. Noda
10) ER-Phagy: Quality and Quantity Control of the Endoplasmic Reticulum by Autophagy
Haruka Chino and Noboru Mizushima
11) ER Membrane Contact Sites, Lipid Transport, and Neurodegeneration
Andrés Guillén-Samander and Pietro De Camilli
12) Sorting and Export of Proteins at the Endoplasmic Reticulum
I. Raote, S. Saxena and Vivek Malhotra
13) Structural Diversity Within the Endoplasmic Reticulum—From the Micron Scale to the Nanoscale
Christopher J. Obara, Andrew S. Moore, and Jennifer Lippincott-Schwartz
14) Cargo Receptor-Mediated ER Export in Lipoprotein Secretion and Lipid Homeostasis
Xiao Wang and Xiao-Wei Chen
15) The Role of ER Architecture in Metabolic Health and Disease
Ana Paula Arruda and Güneş Parlakgül
16) Evolutionary Aspects of the Unfolded Protein Response
Kazutoshi Mori
17) Cholesterol Transport to the Endoplasmic Reticulum
John P. Kennelly and Peter Tontonoz
18) Structure and Function of the Nuclear Pore Complex
Stefan Petrovic, George W. Mobbs, Christopher J. Bley, Si Nie, Alina Patke, and André Hoelz
19) AMPylation and ER Protein Folding Homeostasis
Luke A. Perera and David Ron
20) Regulation and Functions of the ER-Associated Nrf1 Transcription Factor
Gary Ruvkun and Nicolas Lehrbach