` Immune Memory and Vaccines: Great Debates
   

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Immune Memory and Vaccines: Great Debates


Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Immunology and Vaccines

Edited by Shane Crotty, La Jolla Institute for Allergy & Immunology; Rafi Ahmed, Emory Vaccine Center

Download a Free Excerpt from Immune Memory and Vaccines: Great Debates:

Preface
Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment?
Do the Microbiota Influence Vaccines and Protective Immunity to Pathogens?
Index


© 2018 • 418 pages, illustrated (57 color and 5 B&W), index
Hardcover • $135 108.00
ISBN  978-1-621821-54-0
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  •     Description    
  •     Contents    

Description

After an initial encounter with a pathogen, the adaptive immune system creates immune cells that remember the antigens on the pathogen and allow the body to rapidly mount a response during future encounters. Vaccines likewise generate immune memory, preventing the body from succumbing to potentially dangerous infections. Understanding the mechanistic basis of immune memory is therefore essential for designing effective vaccines.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology focuses on the critical questions currently debated in the field of immune memory and vaccination. Topics include the plasticity of memory CD4 T cells, the formation of germinal centers by memory B cells, the contributions of natural killer cells to immune memory, and the influence of commensal microbiota on immune responses. Several contributors respond to each question, providing a variety of fresh, concise perspectives on each topic.

Additional questions address the development and effectiveness of vaccines to various pathogens (e.g., dengue virus and Bordatella pertussis), as well as efforts to develop vaccines against cancer. This volume is therefore valuable for all immunologists, cell biologists, and medical scientists wishing to understand immunological memory, vaccines, and the implications for human health and disease.

Contents

Preface
DO MEMORY CD4 T CELLS KEEP THEIR CELL-TYPE PROGRAMMING: PLASTICITY VERSUS FATE COMMITMENT?
Epigenome: A Dynamic Vehicle for Transmitting and Recording Cytokine Signaling
John L. Johnson and Golnaz Vahedi
T-Cell Heterogeneity Plasticity and Selection in Humans
Federica Sallusto, Antonino Cassotta, Daniel Hoces, Mathilde Foglierini, and Antonio Lanzavecchia
Complexities of Interpretation due to the Heterogeneity of Memory CD4 T Cells, Including T Follicular Helper Cells
Shane Crotty
WHAT ARE THE PRIMARY LIMITATIONS IN B-CELL AFFINITY MATURATION, AND HOW MUCH AFFINITY MATURATION CAN WE DRIVE WITH VACCINATION?
A Role for Antibody Feedback
Kai-Michael Toellner, Daniel M.-Y. Sze, and Yang Zhang
Is Affinity Maturation a Self-Defeating Process for Eliciting Broad Protection?
Christopher T. Stamper and Patrick C. Wilson
Lessons from the Antibody Response to HIV-1
Gabriel D. Victora and Hugo Mouquet
Breaking through Immunity’s Glass Ceiling
Garnett Kelsoe and Barton F. Haynes
WHICH DENGUE VACCINE APPROACH IS THE MOST PROMISING, AND SHOULD WE BE CONCERNED ABOUT ENHANCED DISEASE AFTER VACCINATION?
The Risks of Incomplete Immunity to Dengue Virus Revealed by Vaccination
Stephen S. Whitehead and Kanta Subbarao
The Path to a Dengue Vaccine: Learning from Human Natural Dengue Infection Studies and Vaccine Trials
Aravinda M. de Silva and Eva Harris
Questions Raised by the Development and Implementation of Dengue Vaccines: Example of the Sanofi Pasteur Tetravalent Dengue Vaccine
Bruno Guy
There Is Only One True Winner
Scott B. Halstead
The Challenges of a Dengue Vaccine
Gavin Screaton and Juthathip Mongkolsapaya
IS IT POSSIBLE TO DEVELOP CANCER VACCINES TO NEOANTIGENS, WHAT ARE THE MAJOR CHALLENGES, AND HOW CAN THESE BE OVERCOME?
Neoantigens: Nothing New in Spite of the Name
Olivera J. Finn and Hans-Georg Rammensee
Targeting the Right Antigens in the Right Patients
Stephen P. Schoenberger
Neoantigens as Vaccine Targets for Cancer
Haydn T. Kissick
IS IT POSSIBLE TO DEVELOP A “UNIVERSAL” INFLUENZA VIRUS VACCINE?
Potential Target Antigens and Critical Aspects for a Universal Influenza Vaccine
Florian Krammer, Adolfo García-Sastre, and Peter Palese
Outflanking Antibody Immunodominance on the Road to Universal Influenza Vaccination
Davide Angeletti and Jonathan W. Yewdell
Immunogenetic Considerations Underlying B-Cell Biology in the Development of a Pan-Subtype Influenza AVaccine Targeting the Hemagglutinin Stem
Sarah F. Andrews, Barney S. Graham, John R. Mascola, and Adrian B. McDermott
Potential fora Universal Influenza Vaccine
James E. Crowe, Jr.
DO THE MICROBIOTA INFLUENCE VACCINES AND PROTECTIVE IMMUNITY TO PATHOGENS?
Engaging Our Endogenous Adjuvants
Nicholas Collins and Yasmine Belkaid
If So, Is There Potential for Efficacious Microbiota-Based Vaccines?
Dan R. Littman
Issues of Sovereignty, Federalism, and Points-Testing in the Prokaryotic and Eukaryotic Spaces of the Host-Microbial Superorganism
Andrew J. Macpherson
DO MEMORY B CELLS FORM SECONDARY GERMINAL CENTERS?
Impact of Antibody Class and Quality of Memory T-Cell Help at Recall
Louise J. McHeyzer-Williams, Chad Dufaud, and Michael G. McHeyzer-Williams
It Depends
Kathryn A. Pape and Marc K. Jenkins
Yes and No
Mark J. Shlomchik
WILL SYSTEMS BIOLOGY DELIVER ITS PROMISE AND CONTRIBUTE TO THE DEVELOPMENT OF NEW OR IMPROVED VACCINES?
Seeing the Forest Rather than a Few Trees
Mark M. Davis and Cristina M. Tato
From Data to Understanding through Systems Biology
Thomas Hagan and Bali Pulendran
Systems Biology Views of Vaccine Innate and Adaptive Immunity
Rino Rappuoli, Emilio Siena, and Oretta Finco
What Really Constitutes the Study of “Systems Biology” and How Might Such an Approach Facilitate Vaccine Design
Ronald N. Germain
WHAT IS THE PREDICTIVE VALUE OF ANIMAL MODELS FOR VACCINE EFFICACY IN HUMANS?
The Importance of Bridging Studies and Species-Independent Correlates of Protection
Hana Golding, Surender Khurana, and Marina Zaitseva
Reevaluating the Potential of Mouse Models for the Human Immune System
Stephen C. Jameson and David Masopust
Rigorous Simian Immunodefiency Virus Vaccine Trials Can Be Instructive
Mauricio A. Martins and David I. Watkins
Consideration of Strategies to Improve the Value of Animal Models
Ramin Sedaghat Herati and E. John Wherry
IS A HUMAN CD8 T-CELL VACCINE POSSIBLE, AND IF SO, WHAT WOULD IT TAKE?
CD8 T-Cell Vaccines: To B or Not to B?
Lallt K. Beura, Stephen C. Jameson, and David Masopust
Could a CD8+ T-Cell Vaccine Prevent Persistent HIV Infection?
Andrew J. McMichael
CD8 T-Cell-Mediated Protective Immunity and Vaccination against Enteric Bacteria
Marcelo B. Sztein
WHAT IS WRONG WITH PERTUSSIS VACCINE IMMUNITY?
The Problem of Waning Effectiveness of Pertussis Vaccines
Nicolas Burdin, Lori Kestenbaum Handy, and Stanley A. Plotkin
Why Immunological Memory to Pertussis Is Failing
Dimitri A. Diavatopoulos and Kathryn Margaret Edwards
Inducing and Recalling Vaccine-Specific Immunity
Christiane S. Eberhardt and Claire-Anne Siegrist
WHAT ARE THE MOST POWERFUL IMMUNOGEN DESIGN VACCINE STRATEGIES?
A Structural Biologist’s Perspective
Peter D. Kwong
Reverse Vaccinology 2.0 Shows Great Promise
Dennis R. Burton
IS THERE NATURAL KILLER CELL MEMORY AND CAN IT BE HARNESSED BY VACCINATION?
Natural Killer Cells in Vaccination
Harold R. Neely, Irina B. Mazo, Carmen Gerlach, and Ulrich H. von Andrian
Vaccination Strategies Based on NK Cell and ILC Memory
Megan A. Cooper, Todd A. Fehniger, and Marco Colonna
NK Cell Memory and Immunization Strategies against Infectious Diseases and Cancer
Joseph C. Sun and Lewis L. Lanier
Can Natural Killer and CD8 T Cells Switch Jobs?
Christine A. Biron and Marcus Altfeld
Index