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Malaria: Biology in the Era of Eradication

Subject Area(s):  Human Biology and Disease

Edited by Dyann Wirth, Harvard School of Public Health; Pedro Alonso, University of Barcelona

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© 2017 • 312 pages, illustrated (33 color, 3 B&W), index
Hardcover • $135 94.50 (click here to price in UK Pounds)
ISBN  978-1-621821-22-9
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  •     Description    
  •     Contents    


A renewed global effort in malaria control and elimination over the past decade has led to a substantial increase in basic research and significant advances in our understanding of the mechanisms underlying this complex disease. However, it is not always clear how such gains in knowledge will translate into improved strategies for the fight against malaria.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine explores recent developments in our understanding of malaria biology and their potential to influence malaria elimination/eradication strategies. The authors describe recent developments in their respective research areas and suggest both how these insights could guide intervention strategy and where critical knowledge gaps remain. Contributors discuss the unique features and challenges presented at key stages of the malaria life cycle and by different Plasmodium species, malaria transmission and its interruption, the challenge of drug resistance, the future of malaria vaccine strategies, epigenetic regulation of malaria-associated genes, and new approaches in malaria research, including genomics and modeling. They describe complex interactions of the malaria parasite with the human host, including disease pathogenesis, immune responses, and malaria in pregnancy. They also explore critical developments in vector biology, control, and insecticide resistance and in vector–parasite interactions, including the relationship between mosquito reproduction and parasite development.

The current state of each of these fields, their potential for impact on malaria elimination strategy and critical knowledge gaps, and next steps to achieve this are discussed. This volume is therefore a valuable reference for all scientists, clinicians, and public health professionals interested in understanding the state-of-the-art of malaria biology research and its critical role in our collective ambition to end this devastating disease.


Malaria Transmission and Prospects for Malaria Eradication: The Role of the Environment
Marcia C. Castro
Determinants of Malaria Transmission at the Population Level
Teun Bousema and Chris Drakeley
Biology of Malaria Transmission
Elamaran Meibalan and Matthias Marti
The Biology of Plasmodium vivax
John H. Adams and Ivo Mueller
Anopheline Reproductive Biology: Impacts on Vectorial Capacity and Potential Avenues for Malaria Control
Sara N. Mitchell and Flaminia Catteruccia
Modern Vector Control
Neil F. Lobo, Nicole L. Achee, John Greico, and Frank H. Collins
Current and Future Prospects for Preventing Malaria Transmission via the Use of Insecticides
Hilary Ranson
Plasmodium Sporozoite Biology
Friedrich Frischknecht and Kai Matuschewski
Malaria Parasite Liver Infection and Exoerythrocytic Biology
Ashley M. Vaughan and Stefan H.I. Kappe
Molecular Signaling Involved in Entry and Exit of Malaria Parasites from Host Erythrocytes
Shailja Singh and Chetan E. Chitnis
Host Cell Tropism and Adaptation of Blood-Stage Malaria Parasites: Challenges for Malaria Elimination
Caeul Lim, Selasi Dankwa, Aditya S. Paul, and Manoj T. Duraisingh
Immune Responses in Malaria
Carole A. Long and Fidel Zavala
Malaria Pathogenesis
Danny A. Milner, Jr.
Malaria during Pregnancy
Michal Fried and Patrick E. Duffy
Malaria Genomics in the Era of Eradication
Daniel E. Neafsey and Sarah K. Volkman
Malaria Epigenetics
Alfred Cortés and Kirk W. Deitsch
Antimalarial Drug Resistance: A Threat to Malaria Elimination
Didier Menard and Arjen Dondorp
Vaccines to Accelerate Malaria Elimination and Eventual Eradication
Julie Healer, Alan F. Cowman, David C. Kaslow, and Ashley J. Birkett
Malaria Modeling in the Era of Eradication
Thomas A. Smith, Nakul Chitnis, Melissa Penny, and Marcel Tanner