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Cell Death: Apoptosis and Other Means to an End, Second Edition


Subject Area(s):  Cell Biology

By Douglas R. Green, St. Jude Children’s Research Hospital

Due early 2018 • 250 pages (approx.), illustrated, index
Hardcover • $81 64.80 (click here to price in UK Pounds)
ISBN  978-1-621822-13-4
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Description

Programmed cell death mechanisms, such as apoptosis, play a critical role in development, normal physiology and many diseases, including cancer. This book describes our detailed understanding of the mechanisms involved in apoptosis and other cell death mechanisms, covering signal transducers, caspases, Bcl2-family proteins, mitochondrial molecules and IAPs. The new edition contains critical new information on recent exciting advances in the field, such as new forms for cell death and important insights into the mechanisms and control of apoptosis.

Contents

Foreword
Introduction
1. A Matter of Life and Death
2. Caspases and Their Substrates
3. Caspase Activation and Inhibition
4. The Mitochondrial Pathway of Apoptosis, Part I: MOMP and Beyond
5. The Mitochondrial Pathway of Apoptosis, Part II: The BCL-2 Protein Family
6. The Death Receptor Pathway of Apoptosis
7. Other Caspase Activation Platforms
8. Nonapoptotic Cell Death Pathways
9. The Burial: Clearance and Consequences
10. Cell Death in Development
11. Cell Death and Cancer
12. The Future of Death
Figure Credits
Additional Reading
Index