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Cancer Evolution

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  GenomicsCancer Biology

Edited by Charles Swanton, The Francis Crick Institute; Alberto Bardelli, Candiolo Cancer Institute IRCCS ; Kornelia Polyak, Dana-Farber Cancer Institute, Harvard Medical School; Sohrab Shah, University of British Columbia; Trevor Graham, Barts Cancer Institute, Queen Mary University of London

Due July 2017 • 300 pages (approx.), illustrated, index
Hardcover • $135 94.50 (click here to price in UK Pounds)
ISBN  978-1-621821-43-4
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  •     Description    
  •     Contents    


Cancer occurs because cells develop mutations that confer a growth advantage. Different subpopulations within the tumor can possess different mutations, and new mutations occur as the cancer progresses. This can allow the tumor to develop resistance to chemotherapy and is a major therapeutic challenge. This book examines this quasi-evolutionary process involved and how work in both molecular and computational biology is shedding light on it.


1. Evolution of Premalignant Disease
Kit Curtius, Nicholas A. Wright, and Trevor A. Graham
2. Cancer Stem Cells and Clonal Evolution
Tariq Enver
3. Spatial Heterogeneity in the Tumor Microenvironment
Yinyin Yuan
4. Tumor Microenvironment and Differential Responses to Therapy
Eishu Hirata and Erik Sahai
5. Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity
John D. Martin, Dai Fukumura, Dan G. Duda, Yves Boucher, and Rakesh K. Jain
6. Therapy-Induced Cancer Evolution
Barry Taylor and Joseph Costello
7. Co-Evolution of Leukemia and Host Immune Cells in Chronic Lymphocytic Leukemia (CLL)
Noelia Purroy and Catherine J. Wu
8. Tumor Heterogeneity—The Achilles Heel for Cancer Immunotherapy
Sergio Quezada and Karl Peggs
9. Cancer Drug Resistance in Light of Clonal Evolution: Novel Trial Designs
Robert A. Gatenby
10. Order Matters: The Order of Somatic Mutations Influences Cancer Evolution
David G. Kent and Anthony R. Green
11. The Role of Aneuploidy in Cancer Evolution
Laurent Sansregret and Charles Swanton
12. Principles of Reconstructing the Subclonal Architecture of Cancers
Stefan C. Dentro, David C. Wedge, and Peter Van Loo
13. The Cellular Origin and Evolution of Breast Cancer
Mei Zhang, Adrian V. Lee, and Jeffrey M. Rosen
14. Phylogenetic Quantification of Intra-Tumour Heterogeneity
Thomas B.K. Watkins and Roland F. Schwarz
15. Simulating Cancer Evolution Through Space and Time
Alexander Anderson
16. Big Bang Models of Tumor Evolution
Christina Curtis
17. Lesion-Directed Therapies and Monitoring Tumor Evolution Using Liquid Biopsies
Mariangela Russo and Alberto Bardelli
18. Studies of Clonal Evolution Simulations in Animals Models
Sohrab Shah
19. Chromosomal Instability as a Driver of Tumor Heterogeneity and Evolution
Samuel F. Bakhoum and Dan Avi Landau
20. Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks
Angelo Fortunato, Amy Broddy, Diego Mallo, Athena Aktipis, Carlo C. Maley, and John W. Pepper